Drug reference
Skin Actinic keratosis on face and scalp ▶TO THE SKIN ▶Adult: Apply once daily for 3 days, use the 150 microgram/g gel Actinic keratosis on trunk and extremities ▶TO THE SKIN ▶Adult: Apply once daily for 2 days, use the 500 microgram/g gel
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Avoid contact with broken skin. avoid contact with eyes. avoid contact with inside of ears. avoid contact with inside of nostrils. avoid contact with lips. avoid occlusive dressings on treated area
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MHRA/CHM ADVICE (UPDATED FEBRUARY 2020): INGENOL MEBUTATE GEL (PICATO ®): SUSPENSION OF THE LICENCE DUE TO RISK OF SKIN MALIGNANCY Clinical studies have shown an increased incidence of benign and malignant skin tumours (such as basal and squamous cell carcinoma, Bowen’s disease, and keratoacanthoma) in patients using ingenol mebutate gel; cases of neuroendocrine carcinoma of the skin, and atypical fibroxanthoma have also been reported. Healthcare professionals are advised to stop prescribing ingenol mebutate gel and consider alternative treatment options for actinic keratosis. The licence of ingenol mebutate has been suspended as a precautionary measure while investigations are carried out. Healthcare professionals should advise patients to be vigilant for the development of any new skin lesions within the treatment area and to seek immediate medical advice if any occur.
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▶Common or very common Headache ▶Frequency not known Neoplasms. skin eruption localised
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Not absorbed from skin, but manufacturer advises avoid.
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Not absorbed from skin; ensure infant does not come in contact with treated area for 6 hours after application.
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One tube covers skin area of 25 cm2. Allow gel to dry on treatment area for 15 minutes. Avoid washing or touching the treated area for 6 hours after application; after this time, area may be washed with mild soap and water. Avoid use immediately after shower or less than 2 hours before bedtime.
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No licensed medicines listed. Superficial soft-tissue injuries and superficial thrombophlebitis Topical circulatory preparations Overview These preparations are used to improve circulation in conditions such as bruising, superficial thrombophlebitis, chilblains and varicose veins but are of little value. Chilblains are best managed by avoidance of exposure to cold; neither systemic nor topical vasodilator therapy is established as being effective. HEPARINOIDS Skin
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Apply once daily for 3 days, use the
First-line fragment. Read the complete Indications and Dose section above.
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Apply once daily for 2 days, use the
First-line fragment. Read the complete Indications and Dose section above.
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