Drug reference

Isosorbide dinitrate

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 255, 256

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

Prophylaxis and treatment of angina ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Adult: 30–120 mg daily in divided doses ▶BY INTRAVENOUS INFUSION ▶Adult: 2–10 mg/hour, increased if necessary up to 20 mg/hour ▶BY SUBLINGUAL ADMINISTRATION USING AEROSOL SPRAY ▶Adult: 1–3 sprays, to be administered under tongue whilst holding breath, allow a 30 second interval between each dose Left ventricular failure ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Adult: 40–160 mg daily in divided doses, increased if necessary up to 240 mg daily in divided doses ▶BY INTRAVENOUS INFUSION ▶Adult: Initially 2–10 mg/hour, increased if necessary up to 20 mg/hour Prophylaxis of angina ▶BY MOUTH USING MODIFIED-RELEASE MEDICINES ▶Adult: 40 mg daily in 1–2 divided doses, increased if necessary to 60–80 mg daily in 2–3 divided doses

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Safety

Interactions

→Appendix 1: nitrates

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Side Effects

▶Common or very common ▶With oral use Peripheral oedema ▶Rare or very rare ▶With oral use Angioedema. angle closure glaucoma. hypoventilation. hypoxia. pituitary haemorrhage. Stevens-Johnson syndrome

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Pregnancy

May cross placenta—manufacturers advise avoid unless potential beneﬁt outweighs risk.

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Dose and formulations

Directions For Administration

For intravenous infusion (Isoket 0.05% ®, Isoket 0.1% ®), give continuously in Cardiovascular system Glucose 5% or Sodium chloride 0.9%. Adsorbed to some extent by polyvinyl chloride infusion containers; preferably use glass or polyethylene containers or give via a syringe pump; Isoket 0.05% ® can alternatively be administered undiluted using a syringe pump with a glass or rigid plastic syringe. Glass or polyethylene infusion apparatus is preferable; loss of potency if PVC used.

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Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: oral suspension, oral solution Modified-release tablet CAUTIONARY AND ADVISORY LABELS 25 ▶Isoket Retard (Forum Health Products Ltd) Isosorbide dinitrate 20 mg Isoket Retard 20 tablets | 56 tablet p £2.58 DT = £2.58 Isosorbide dinitrate 40 mg Isoket Retard 40 tablets | 56 tablet p £6.36 DT = £6.36 Tablet ▶Isosorbide dinitrate (Non-proprietary) Isosorbide dinitrate 10 mg Isosorbide dinitrate 10mg tablets | 56 tablet p £34.00 DT = £16.85 Isosorbide dinitrate 20 mg Isosorbide dinitrate 20mg tablets | 56 tablet P s DT = £16.65 Solution for injection ▶Isosorbide dinitrate (Non-proprietary) Isosorbide dinitrate 1 mg per 1 ml Isosorbide dinitrate 10mg/10ml concentrate for solution for injection ampoules | 10 ampoule P £29.00 ▶Isoket (Forum Health Products Ltd) Isosorbide dinitrate 1 mg per 1 ml Isoket 0.1% solution for injection 10ml ampoules | 10 ampoule P £26.93 (Hospital only) Solution for infusion ▶Isosorbide dinitrate (Non-proprietary) Isosorbide dinitrate 500 microgram per 1 ml Isosorbide dinitrate 25mg/50ml solution for infusion vials | 10 vial P £65.80 Isosorbide dinitrate 1 mg per 1 ml Isosorbide dinitrate 50mg/50ml concentrate for solution for infusion vials | 10 vial P £85.00 eiiii F 231

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Dose text by age group

Adult

30–120 mg daily in divided doses

First-line fragment. Read the complete Indications and Dose section above.

PDF page 255

Adult

2–10 mg/hour, increased if necessary up to

First-line fragment. Read the complete Indications and Dose section above.

PDF page 255

Adult

1–3 sprays, to be administered under tongue

First-line fragment. Read the complete Indications and Dose section above.

PDF page 255

Adult

40–160 mg daily in divided doses, increased if

First-line fragment. Read the complete Indications and Dose section above.

PDF page 255

Adult

Initially 2–10 mg/hour, increased if necessary up

First-line fragment. Read the complete Indications and Dose section above.

PDF page 255

Adult

40 mg daily in 1–2 divided doses, increased if

First-line fragment. Read the complete Indications and Dose section above.

PDF page 255

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

Isosorbide dinitrate

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 255, 256

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

PDF page 255

Safety

Interactions

→Appendix 1: nitrates

PDF page 255

Side Effects

PDF page 255

Pregnancy

May cross placenta—manufacturers advise avoid unless potential beneﬁt outweighs risk.

PDF page 256

Dose and formulations

Directions For Administration

PDF page 256

Medicinal Forms

PDF page 256

Dose text by age group

Adult

30–120 mg daily in divided doses

First-line fragment. Read the complete Indications and Dose section above.

PDF page 255

Adult

2–10 mg/hour, increased if necessary up to

First-line fragment. Read the complete Indications and Dose section above.

PDF page 255

Adult

1–3 sprays, to be administered under tongue

First-line fragment. Read the complete Indications and Dose section above.

PDF page 255

Adult

40–160 mg daily in divided doses, increased if

First-line fragment. Read the complete Indications and Dose section above.

PDF page 255

Adult

Initially 2–10 mg/hour, increased if necessary up

First-line fragment. Read the complete Indications and Dose section above.

PDF page 255

Adult

40 mg daily in 1–2 divided doses, increased if

First-line fragment. Read the complete Indications and Dose section above.

PDF page 255

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.