Therapeutic Action
Vasodilator, antianginal
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Drug reference
Vasodilator, antianginal
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Adjunctive therapy in acute heart failure (acute pulmonary oedema)
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Do not administer to patients with obstructive cardiomyopathy, hypotension, shock, intracranial hypertension or neurologic injury. May cause: orthostatic hypotension (especially in older patients), headache, nausea, flushing of the face, haemolytic anaemia in patients with G6PD deficiency; severe hypotension with risk of circulatory collapse in the event of overdose. Avoid combination or use the lowest effective dose in patients taking another nitrate derivative, a vasodilator, a diuretic or an antihypertensive drug (enhances hypotensive effects), and in older patients. Do not combine with sildenafil or other drugs used for erectile dysfunction (risk of severe hypotension, syncope and acute coronary syndrome). Pregnancy and breast-feeding: avoid, use only if clearly needed (safety not established)
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10 mg in 10 ml ampoule (1 mg/ml), for slow IV injection or IV infusion in 5% glucose or 0.9% sodium chloride
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Adult: 2 mg (= 2 ml) by slow IV injection (2 minutes) then, if necessary, 2 to 10 mg/hour by continuous infusion with an electric syringe pump Monitor blood pressure during administration. The objective is to lower the systolic pressure to 120-150 mmHg and the diastolic pressure to under 110 mmHg.
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Injectable isosorbide dinitrate is not included in the WHO list of essential medicines.
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Below 25 °C
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2 mg (= 2 ml) by slow IV injection (2 minutes) then, if necessary, 2 to 10 mg/hour by continuous infusion with an electric syringe pump
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