Drug reference

Isosorbide mononitrate

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 256, 257

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

Prophylaxis of angina | Adjunct in congestive heart failure ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Adult: Initially 20 mg 2–3 times a day, alternatively initially 40 mg twice daily, increased if necessary up to 120 mg daily in divided doses Prophylaxis of angina (for patients who have not previously had a nitrate) | Adjunct in congestive heart failure (for patients who have not previously had a nitrate) ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Adult: Initially 10 mg twice daily, increased if necessary up to 120 mg daily in divided doses CHEMYDUR ® 60XL Prophylaxis of angina ▶BY MOUTH ▶Adult: Initially 0.5 tablet daily for 2–4 days, to minimise possibility of headache, then 1 tablet daily, increased if necessary to 2 tablets daily, dose to be taken in the morning ELANTAN ® LA Prophylaxis of angina ▶BY MOUTH ▶Adult: 25–50 mg once daily, then increased if necessary to 50–100 mg once daily, dose to be taken in the morning, the lowest effective dose should be used IMDUR ® Prophylaxis of angina ▶BY MOUTH ▶Adult: Initially 0.5 tablet once daily, to minimise the occurrence of headache, then 1 tablet once daily, then increased if necessary to 2 tablets once daily, dose to be taken in the morning ISIB ® 60XL Prophylaxis of angina ▶BY MOUTH ▶Adult: Initially 0.5 tablet once daily for 2–4 days, to minimise the occurrence of headache, then 1 tablet once daily, increased if necessary to 2 tablets once daily, dose to be taken in the morning ISMO RETARD ® Prophylaxis of angina ▶BY MOUTH ▶Adult: 1 tablet once daily, dose to be taken in the morning ISODUR ® Prophylaxis of angina ▶BY MOUTH ▶Adult: 25–50 mg once daily, then increased if necessary to 50–100 mg once daily, dose to be taken in the morning ISOTARD ® Prophylaxis of angina ▶BY MOUTH ▶Adult: 25–60 mg once daily, if headaches occur with 60 mg tablet, half a 60 mg tablet may be given for 2–4 days, then increased if necessary to 50–120 mg once daily, dose to be taken in the morning MODISAL ® XL Prophylaxis of angina ▶BY MOUTH ▶Adult: Initially 0.5 tablet once daily for 2–4 days, to minimise the occurrence of headache, then 1 tablet once daily, increased if necessary to 2 tablets once daily, dose to be taken in the morning MONOMAX ® XL Prophylaxis of angina ▶BY MOUTH ▶Adult: Initially 0.5 tablet once daily for 2–4 days, to minimise occurrence of headache, then 1 tablet once daily, increased if necessary to 2 tablets once daily, dose to be taken in the morning MONOMIL ® XL Prophylaxis of angina ▶BY MOUTH ▶Adult: Initially 0.5 tablet daily for 2–4 days, to minimise possibility of headache, then 1 tablet daily, increased if necessary to 2 tablets once daily, to be taken in the morning MONOSORB ® XL60 Prophylaxis of angina ▶BY MOUTH ▶Adult: Initially 0.5 tablet once daily for the ﬁrst 2–4 days, to minimise the occurrence of headache, then 1 tablet once daily, increased if necessary to 2 tablets once daily, dose to be taken in the morning ZEMON ® Prophylaxis of angina ▶BY MOUTH ▶Adult: Initially 30 mg once daily for 2–4 days, to minimise the occurrence of headache, then 40–60 mg once daily, increased if necessary to 80–120 mg once daily, dose to be taken in the morning

PDF page 256

Safety

Interactions

→Appendix 1: nitrates

PDF page 257

Side Effects

▶Rare or very rare Myalgia

PDF page 257

Pregnancy

Manufacturers advise avoid unless potential beneﬁt outweighs risk.

PDF page 257

Dose and formulations

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: oral suspension, oral solution Modified-release tablet CAUTIONARY AND ADVISORY LABELS 25 ▶Carmil XL (Milpharm Ltd) Isosorbide mononitrate 60 mg Carmil XL 60mg tablets | 28 tablet p £5.75 DT = £10.50 ▶Chemydur 60XL (Advanz Pharma) Isosorbide mononitrate 60 mg Chemydur 60XL tablets | 28 tablet p £3.49 DT = £10.50 ▶Imdur (TopRidge Pharma (Ireland) Ltd) Isosorbide mononitrate 60 mg Imdur 60mg modified-release tablets | 28 tablet p £10.50 DT = £10.50 ▶Isib XL (Alliance Pharmaceuticals Ltd) Isosorbide mononitrate 60 mg Isib 60XL tablets | 28 tablet p £8.15 DT = £10.50 ▶Ismo Retard (Intrapharm Laboratories Ltd) Isosorbide mononitrate 40 mg Ismo Retard 40mg tablets | 30 tablet p £10.71 ▶Isotard XL (Kyowa Kirin Ltd) Isosorbide mononitrate 25 mg Isotard 25XL tablets | 28 tablet p £6.75 DT = £6.75 Isosorbide mononitrate 40 mg Isotard 40XL tablets | 28 tablet p £6.75 DT = £6.75 Isosorbide mononitrate 50 mg Isotard 50XL tablets | 28 tablet p £6.75 DT = £6.75 Isosorbide mononitrate 60 mg Isotard 60XL tablets | 28 tablet p £5.75 DT = £10.50 ▶Modisal XL (Ennogen Pharma Ltd) Isosorbide mononitrate 40 mg Modisal XL 40mg tablets | 28 tablet P £5.40 DT = £6.75 ▶Monomax XL (Chiesi Ltd) Isosorbide mononitrate 60 mg Monomax XL 60mg tablets | 28 tablet p £5.25 DT = £10.50 ▶Monomil XL (Teva UK Ltd) Isosorbide mononitrate 60 mg Monomil XL 60mg tablets | 28 tablet p £3.49 DT = £10.50 ▶Monosorb XL (Dexcel-Pharma Ltd) Isosorbide mononitrate 60 mg Monosorb XL 60 tablets | 28 tablet p £15.53 DT = £10.50 ▶Relosorb XL (Relonchem Ltd) Isosorbide mononitrate 60 mg Relosorb XL 60mg tablets | 28 tablet P £22.45 DT = £10.50 ▶Tardisc XL (Dexcel-Pharma Ltd) Isosorbide mononitrate 60 mg Tardisc XL 60 tablets | 28 tablet p £3.49 DT = £10.50 ▶Trangina XL (Accord Healthcare Ltd) Isosorbide mononitrate 60 mg Trangina XL 60mg tablets | 28 tablet P £4.55 DT = £10.50 ▶Xismox XL (Genus Pharmaceuticals Ltd) Isosorbide mononitrate 60 mg Xismox XL 60 tablets | 28 tablet P £5.51 DT = £10.50 ▶Zemon XL (Kent Pharmaceuticals Ltd) Isosorbide mononitrate 40 mg Zemon 40 XL tablets | 28 tablet p £14.25 DT = £6.75 Tablet CAUTIONARY AND ADVISORY LABELS 25 ▶Isosorbide mononitrate (Non-proprietary) Isosorbide mononitrate 10 mg Isosorbide mononitrate 10mg tablets | 56 tablet P £0.40–£13.10 DT = £1.17 Isosorbide mononitrate 20 mg Isosorbide mononitrate 20mg tablets | 56 tablet P £0.41–£13.88 DT = £1.35 Isosorbide mononitrate 40 mg Isosorbide mononitrate 40mg tablets | 56 tablet P £0.34–£20.55 DT = £1.79 ▶Ismo (Intrapharm Laboratories Ltd) Isosorbide mononitrate 10 mg Ismo 10 tablets | 60 tablet p £2.98 Isosorbide mononitrate 20 mg Ismo 20 tablets | 60 tablet p £4.12 Modified-release capsule CAUTIONARY AND ADVISORY LABELS 25 ▶Elantan LA (Forum Health Products Ltd) Isosorbide mononitrate 25 mg Elantan LA25 capsules | 28 capsule p £3.40 DT = £3.40 Cardiovascular system Isosorbide mononitrate 50 mg Elantan LA50 capsules | 28 capsule p £3.69 DT = £3.69 ▶Isodur XL (Galen Ltd) Isosorbide mononitrate 25 mg Isodur 25XL capsules | 28 capsule p £4.63 DT = £3.40 Isosorbide mononitrate 50 mg Isodur 50XL capsules | 28 capsule p £6.45 DT = £3.69 ▶Monomax SR (Ethypharm UK Ltd) Isosorbide mononitrate 40 mg Nyzamac SR 40mg capsules | 28 capsule p £6.52 DT = £6.52 Isosorbide mononitrate 60 mg Nyzamac SR 60mg capsules | 28 capsule p £8.86 DT = £8.86 SYMPATHOMIMETICS › INOTROPIC

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Dose text by age group

Adult

Initially 20 mg 2–3 times a day, alternatively

First-line fragment. Read the complete Indications and Dose section above.

PDF page 256

Adult

Initially 10 mg twice daily, increased if necessary

First-line fragment. Read the complete Indications and Dose section above.

PDF page 256

Adult

Initially 0.5 tablet daily for 2–4 days, to

First-line fragment. Read the complete Indications and Dose section above.

PDF page 256

Adult

25–50 mg once daily, then increased if necessary

First-line fragment. Read the complete Indications and Dose section above.

PDF page 256

Adult

Initially 0.5 tablet once daily, to minimise the

First-line fragment. Read the complete Indications and Dose section above.

PDF page 256

Adult

Initially 0.5 tablet once daily for 2–4 days, to

First-line fragment. Read the complete Indications and Dose section above.

PDF page 256

Adult

1 tablet once daily, dose to be taken in the

First-line fragment. Read the complete Indications and Dose section above.

PDF page 256

Adult

25–50 mg once daily, then increased if necessary

First-line fragment. Read the complete Indications and Dose section above.

PDF page 256

Adult

25–60 mg once daily, if headaches occur with

First-line fragment. Read the complete Indications and Dose section above.

PDF page 256

Adult

Initially 0.5 tablet once daily for 2–4 days, to

First-line fragment. Read the complete Indications and Dose section above.

PDF page 256

Adult

Initially 0.5 tablet once daily for 2–4 days, to

First-line fragment. Read the complete Indications and Dose section above.

PDF page 256

Adult

Initially 0.5 tablet daily for 2–4 days, to

First-line fragment. Read the complete Indications and Dose section above.

PDF page 256

Adult

Initially 0.5 tablet once daily for the ﬁrst

First-line fragment. Read the complete Indications and Dose section above.

PDF page 256

Adult

Initially 30 mg once daily for 2–4 days, to

First-line fragment. Read the complete Indications and Dose section above.

PDF page 256

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

Isosorbide mononitrate

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 256, 257

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

PDF page 256

Safety

Interactions

→Appendix 1: nitrates

PDF page 257

Side Effects

▶Rare or very rare Myalgia

PDF page 257

Pregnancy

Manufacturers advise avoid unless potential beneﬁt outweighs risk.

PDF page 257

Dose and formulations

Medicinal Forms

PDF page 257

Dose text by age group

Adult

Initially 20 mg 2–3 times a day, alternatively

First-line fragment. Read the complete Indications and Dose section above.

PDF page 256

Adult

Initially 10 mg twice daily, increased if necessary

First-line fragment. Read the complete Indications and Dose section above.

PDF page 256

Adult

Initially 0.5 tablet daily for 2–4 days, to

First-line fragment. Read the complete Indications and Dose section above.

PDF page 256

Adult

25–50 mg once daily, then increased if necessary

First-line fragment. Read the complete Indications and Dose section above.

PDF page 256

Adult

Initially 0.5 tablet once daily, to minimise the

First-line fragment. Read the complete Indications and Dose section above.

PDF page 256

Adult

Initially 0.5 tablet once daily for 2–4 days, to

First-line fragment. Read the complete Indications and Dose section above.

PDF page 256

Adult

1 tablet once daily, dose to be taken in the

First-line fragment. Read the complete Indications and Dose section above.

PDF page 256

Adult

25–50 mg once daily, then increased if necessary

First-line fragment. Read the complete Indications and Dose section above.

PDF page 256

Adult

25–60 mg once daily, if headaches occur with

First-line fragment. Read the complete Indications and Dose section above.

PDF page 256

Adult

Initially 0.5 tablet once daily for 2–4 days, to

First-line fragment. Read the complete Indications and Dose section above.

PDF page 256

Adult

Initially 0.5 tablet once daily for 2–4 days, to

First-line fragment. Read the complete Indications and Dose section above.

PDF page 256

Adult

Initially 0.5 tablet daily for 2–4 days, to

First-line fragment. Read the complete Indications and Dose section above.

PDF page 256

Adult

Initially 0.5 tablet once daily for the ﬁrst

First-line fragment. Read the complete Indications and Dose section above.

PDF page 256

Adult

Initially 30 mg once daily for 2–4 days, to

First-line fragment. Read the complete Indications and Dose section above.

PDF page 256

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.