Indications And Dose
Controlled hypotension in anaesthesia ▶BY INTRAVENOUS INFUSION, OR BY INTRAVENOUS INJECTION ▶Adult: (consult product literature or local protocols) Hypertension of pregnancy ▶BY INTRAVENOUS INFUSION ▶Adult: Initially 20 mg/hour, then increased if necessary to 40 mg/hour after 30 minutes, then increased if necessary to 80 mg/hour after 30 minutes, then increased if necessary to 160 mg/hour after 30 minutes, adjusted according to response; Usual maximum 160 mg/hour ▶BY MOUTH ▶Adult: Use dose for hypertension Hypertension following myocardial infarction ▶BY INTRAVENOUS INFUSION ▶Adult: 15 mg/hour, then increased to up to 120 mg/hour, dose to be increased gradually Hypertensive emergencies ▶BY INTRAVENOUS INJECTION ▶Adult: 50 mg, to be given over at least 1 minute, then 50 mg every 5 minutes if required until a satisfactory response occurs; maximum 200 mg per course ▶BY INTRAVENOUS INFUSION ▶Adult: Initially 2 mg/minute until a satisfactory response is achieved, then discontinue; usual dose 50–200 mg Hypertension ▶BY MOUTH ▶Adult: Initially 100 mg twice daily, dose to be increased at intervals of 14 days; usual dose 200 mg twice daily, increased if necessary up to 800 mg daily in 2 divided doses, to be taken with food, higher doses to be given in 3–4 divided doses; maximum 2.4 g per day ▶Elderly: Initially 50 mg twice daily, dose to be increased at intervals of 14 days; usual dose 200 mg twice daily, increased if necessary up to 800 mg daily in 2 divided doses, to be taken with food, higher doses to be given in 3–4 divided doses; maximum 2.4 g per day ▶BY INTRAVENOUS INJECTION ▶Adult: 50 mg, dose to be given over at least 1 minute, then 50 mg after 5 minutes if required; maximum 200 mg per course ▶BY INTRAVENOUS INFUSION ▶Adult: Initially 2 mg/minute until a satisfactory response is achieved, then discontinue; usual dose 50–200 mg
PDF page 182