Indications And Dose
HIV-1 infection (initiated by a specialist) ▶BY MOUTH ▶Adult: 1 tablet once daily
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Drug reference
HIV-1 infection (initiated by a specialist) ▶BY MOUTH ▶Adult: 1 tablet once daily
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DUE TO INTERACTIONS ▶Manufacturer advises if concurrent use of moderate inducers of CYP3A4, dabrafenib, modafinil or telotristat ethyl is unavoidable, increase doravirine dose to 100 mg twice daily. Manufacturer advises increasing doravirine dose to 100 mg twice daily with rifabutin. The extra doravirine 100 mg dose should be taken approximately 12 hours after the dose of Delstrigo ®.
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→Appendix 1: doravirine. lamivudine. tenofovir disoproxil
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Manufacturer advises avoid.
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Manufacturer advises caution in severe impairment—no information available.
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Manufacturer advises avoid if creatinine clearance less than 50 mL/minute.
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There can be variation in the licensing of different medicines containing the same drug. Tablet CAUTIONARY AND ADVISORY LABELS 25, 3 ▶Delstrigo (Merck Sharp & Dohme Ltd) A Doravirine 100 mg,Tenofovir disoproxil (as Tenofovir disoproxil fumarate) 245 mg, Lamivudine 300 mg Delstrigo 100mg/300mg/245mg tablets | 30 tablet P £578.55 eiiii F 683
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Missed doses If a dose is more than 12 hours late, the missed dose should not be taken and the next dose should be taken at the normal time. Driving and skilled tasks Manufacturer advises patients and carers should be counselled on the effects on driving and performance of skilled tasks—increased risk of fatigue, dizziness, and somnolence.
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1 tablet once daily
First-line fragment. Read the complete Indications and Dose section above.
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