Names and pronunciation
(la-pa′tin-ib) Tykerb
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Drug reference
(la-pa′tin-ib) Tykerb
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Func. class.: Antineoplastic—miscel- laneous
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Chem. class.: Biologic response modi- fier, signal transduction inhibitor (STIs)
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USES: Advanced metastatic breast can- cer patients with tumor that overexpresses HER2 protein and who have received pre- vious chemotherapy
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CONTRAINDICATIONS: Preg- nancy, breastfeeding, hypersensitivity
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Black Box Warning: Hepatotoxicity
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DOSAGE AND ROUTES Advanced/metastatic breast cancer with HER2 overexpression who have received previous therapy • Adult: Lapatinib PO 1250 mg (5 tabs)/ day 1 hr before or after food on days 1-21 plus capecitabine 2000 mg/m2/ day in 2 divided doses on days 1-14 in a repeating 21-day cycle; continue until therapeutic response or toxicity occurs Lapatinib/letrozole combination • Adult: PO lapatinib 1500 mg (6 tablets) q2days with letrozole PO 2.5 mg daily Metastatic breast cancer with HER2 overexpression for whom hormonal therapy is indicated • Adult: PO 1500 mg (6 tabs) 1 hr be- fore food with letrozole 2.5 mg/day Hepatic dose • Adult: PO (Child-Pugh C) 750 mg/day (with capecitabine); 1000 mg/day (with letrozole)
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Available forms: Tabs 250 mg HIGH ALERT
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• Adult: Lapatinib PO 1250 mg (5 tabs)/ day 1 hr before or after food on days 1-21 plus capecitabine 2000 mg/m2/ day in 2 divided doses on days 1-14 in a repeating 21-day cycle; continue until therapeutic response or toxicity occurs Lapatinib/letrozole combination
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• Adult: PO lapatinib 1500 mg (6 tablets) q2days with letrozole PO 2.5 mg daily Metastatic breast cancer with HER2 overexpression for whom hormonal therapy is indicated
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• Adult: PO 1500 mg (6 tabs) 1 hr be- fore food with letrozole 2.5 mg/day Hepatic dose
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• Adult: PO (Child-Pugh C) 750 mg/day (with capecitabine); 1000 mg/day (with letrozole)
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