Names and pronunciation
(layr′oh-trek′tih-nib) Vitrakvi
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Drug reference
(layr′oh-trek′tih-nib) Vitrakvi
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Func. class.: Antineoplastic—TRK inhibitor
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USES: Metastatic or surgically unre- sectable neurotrophic receptor tyrosine kinase (NTRK) gene fusion–positive solid tumors with no known acquired resistance mutation, in patients with no satisfactory alternative treatments or in patients who have progressed following treatment
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CONTRAINDICATIONS: Hyper- sensitivity, pregnancy
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DOSAGE AND ROUTES • Adult/adolescent/child/infant: PO For BSA ≥1 m2, 100 mg bid; for BSA <1 m2, 100 mg/m2 bid; continue therapy until disease progression
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Available forms: Oral solution 20 mg/ mL; capsules 25, 100 mg
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• Adult/adolescent/child/infant: PO For BSA ≥1 m2, 100 mg bid; for BSA <1 m2, 100 mg/m2 bid; continue therapy until disease progression
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