Indications And Dose
Raised intra-ocular pressure in open-angle glaucoma | Ocular hypertension ▶TO THE EYE ▶Adult: Apply once daily, to be administered preferably in the evening
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Drug reference
Raised intra-ocular pressure in open-angle glaucoma | Ocular hypertension ▶TO THE EYE ▶Adult: Apply once daily, to be administered preferably in the evening
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Active herpes simplex keratitis. history of recurrent herpetic keratitis associated with prostaglandin analogues
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Angle-closure glaucoma. aphakia. asthma. contact lens wearers. do not use within 5 minutes of thiomersal-containing preparations. history of significant ocular viral infections. inflammatory ocular conditions (no experience of use). narrow-angle glaucoma (no experience of use). neovascular glaucoma (no experience of use). peri-operative period of cataract surgery. pseudophakia with torn posterior lens capsule or anterior chamber lenses . risk factors for cystoid macular oedema. risk factors for iritis. risk factors for uveitis
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Although multi-dose latanoprost eye drops commonly contain preservatives, preservative-free unit dose vials may be available.
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MONOPOST ® Scottish Medicines Consortium (SMC) decisions The Scottish Medicines Consortium has advised (July 2013) that Monopost ® is accepted for restricted use within NHS Scotland for the reduction of elevated intra-ocular pressure in patients with open-angle glaucoma and ocular hypertension who have proven sensitivity to benzalkonium chloride.
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MHRA/CHM ADVICE: LATANOPROST (XALATAN ®): INCREASED REPORTING OF EYE IRRITATION SINCE REFORMULATION (JULY 2015) Following reformulation of Xalatan ®, to allow for long- term storage at room temperature, there has been an increase in the number of reports of eye irritation from across the EU. Patients should be advised to tell their health professional promptly (within a week) if they experience eye irritation (e.g. excessive watering) severe enough to make them consider stopping treatment. Review treatment and prescribe a different formulation if necessary.
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▶Common or very common Eye discolouration. eye discomfort. eye disorders. eye inflammation. vision disorders ▶Uncommon Dry eye. rash ▶Rare or very rare Asthma. chest pain. dyspnoea. unstable angina ▶Frequency not known Arthralgia. dizziness. headache. myalgia. ophthalmic herpes simplex. palpitations
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Manufacturer advises avoid.
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May be present in milk—manufacturer advises avoid.
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There can be variation in the licensing of different medicines containing the same drug. Eye drops EXCIPIENTS: May contain Benzalkonium chloride ▶Latanoprost (Non-proprietary) Latanoprost 50 microgram per 1 ml Latanoprost 50micrograms/ml eye drops | 2.5 ml P £12.48 DT = £4.05 ▶Medizol (Medicom Healthcare Ltd) Latanoprost 50 microgram per 1 ml Medizol 0.005% eye drops | 2.5 ml P s DT = £4.05 ▶Monopost (Thea Pharmaceuticals Ltd) Latanoprost 50 microgram per 1 ml Monopost 50micrograms/ml eye drops 0.2ml unit dose | 30 unit dose P £8.49 DT = £8.49 | 90 unit dose P £25.47 DT = £25.47 ▶Xalatan (Upjohn UK Ltd) Latanoprost 50 microgram per 1 ml Xalatan 50micrograms/ml eye drops | 2.5 ml P £12.48 DT = £4.05
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Changes in eye colour Before initiating treatment, patients should be warned of a possible change in eye colour as an increase in the brown pigment in the iris can occur, which may be permanent; particular care is required in those with mixed coloured irides and those receiving treatment to one eye only. Changes in eyelashes and vellus hair can Eye also occur, and patients should also be advised to avoid repeated contact of the eye drop solution with skin as this can lead to hair growth or skin pigmentation.
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Apply once daily, to be administered preferably
First-line fragment. Read the complete Indications and Dose section above.
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