Names and pronunciation
(lah-tan′oh-prost) Xalatan
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Drug reference
(lah-tan′oh-prost) Xalatan
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Func. class.: Antiglaucoma agent
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Chem. class.: Prostaglandin agonist
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Do not confuse: latanoprost/bimatoprost
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ACTION: Increases aqueous humor outflow
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USES: Increased intraocular pres- sure in those who have open-angle glaucoma/ocular hypertension and who do not respond to other IOP-low- ering products
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CONTRAINDICATIONS: Hyper- sensitivity to this product, benzalkonium chloride Precautions: Eye infections, angle- closure glaucoma, renal/hepatic function impairment, children, contact lenses, uveitis, keratitis
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SIDE EFFECTS EENT: Conjunctival hyperemia, iris color change, ocular pruritus, xeroph- thalmia, visual disturbance, ocular irrita- tion/burning, foreign body sensation, ocular pain, blepharitis, cataracts, and superficial punctate keratitis INTEG: Rash, allergic reactions MISC: Flulike symptoms CV: Angina
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DOSAGE AND ROUTES • Adult: OPHTH Instill 1 drop in each affected eye (conjunctival sac) every night
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Available forms: Ophthalmic solution 0.005% (50 mcg/mL)
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Administer: Ophthalmic route • Wash hands before and after use; con- tact lenses should be removed before L using the product, reinsert 15 min after use; contains benzalkonium chloride, which may be absorbed by soft contact lenses • The solution may be used concomitantly with other topical ophthalmic drug prod- ucts to lower IOP; if more than one topical ophthalmic drug is being used, the drugs should be administered at least 5 min apart • Store unopened bottle refrigerated; once opened, it may be stored at room tempera- ture, protected from light, for up to 6 wk
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Assess: • Intraocular pressure: in those with on- going increased IOP
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Evaluate: • Therapeutic response: decreasing IOP
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CLINICAL CONSIDERATIONS
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Patient and caregiver information: Ophthalmic route • To wash hands before and after use; that contact lenses should be removed, reinsert 15 min after use; contains benz alkonium chloride, which may be ab- sorbed by soft contact lenses • Tilt the head back slightly and pull lower eyelid down to form a pouch; squeeze drops into the pouch and close the eyes for 1-2 min; not to blink; to avoid contamination, do not touch the tip of the dropper to the eye, fingertips, or other surface • May be used concomitantly with other topical ophthalmic products to lower IOP; if more than one is used, the drugs should be administered at least 5 min apart, do not exceed dose • To store unopened bottle refrigerated; once opened, it may be stored at room temperature, protected from light, for up to 6 wk HIGH ALERT
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PHARMACOKINETICS Ophthalmic: Onset 3-4 hr, peak 8-12 hr; half-life 3 hr
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• Adult: OPHTH Instill 1 drop in each affected eye (conjunctival sac) every night
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