Names and pronunciation
(le-term-oh-vir) Prevymis
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Drug reference
(le-term-oh-vir) Prevymis
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Func. class.: Antiviral
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USES: For the prevention of cytomega- lovirus following allogenic hematopoietic stem cell transplant
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DOSAGE AND ROUTES Cytomegalovirus (CMV) disease prophylaxis • Adult: PO/IV 480 mg/day started bet ween day 0 and day 28 after transplantation (before or after engraftment) and continued through day 100 after transplantation Cytomegalovirus (CMV) disease prophylaxis in patients with concurrent cycloSPORINE • Adult: PO/IV 240 mg/day started be- tween day 0 and day 28 after transplanta- tion (before or after engraftment) and continued through day 100 after trans- plantation. If cyclosporine is initiated after starting letermovir, reduce letermovir to 240 mg with the next dose. If cyclosporine is discontinued after starting letermovir, increase the dose of letermovir to 480 mg. If cyclosporine dosing is interrupted due to high cyclosporine concentrations, no dosage adjustment of letermovir is needed
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Available forms: Tabs 240, 480 mg; injection 240 mg/12 mL; 480 mg/24 mL single-use vials HIGH ALERT
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• Adult: PO/IV 480 mg/day started bet ween day 0 and day 28 after transplantation (before or after engraftment) and continued through day 100 after transplantation Cytomegalovirus (CMV) disease prophylaxis in patients with concurrent cycloSPORINE
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• Adult: PO/IV 240 mg/day started be- tween day 0 and day 28 after transplanta- tion (before or after engraftment) and continued through day 100 after trans- plantation. If cyclosporine is initiated after starting letermovir, reduce letermovir to 240 mg with the next dose. If cyclosporine is discontinued after starting letermovir, increase the dose of letermovir to 480 mg. If cyclosporine dosing is interrupted due to high cyclosporine concentrations, no dosage adjustment of letermovir is needed
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