Names and pronunciation
(loo-koe-vor′in)
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Drug reference
(loo-koe-vor′in)
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Func. class.: Vitamin, folic acid/ methotrexate antagonist antidote
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Chem. class.: Tetrahydrofolic acid derivative
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Do not confuse: leucovorin/Leukeran/levoleucovorin
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USES: Megaloblastic or macrocytic anemia caused by folic acid deficiency, overdose of folic acid antagonist, metho- trexate/pyrimethamine/trimetrexate/ trimethoprim toxicity, pneumocystosis, toxoplasmosis
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CONTRAINDICATIONS: Hyper- sensitivity to this product or folic acid, benzyl alcohol; anemias other than meg- aloblastic not associated with vit B12 deficiency
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DOSAGE AND ROUTES Methotrexate toxicity/leucovorin rescue • Adult/child: PO/IM/IV normal elim- ination given 6 hr after dose of metho- trexate (10 mg/m2) until methotrexate <5 × 10−8 m, CCr >50% above prior level, or methotrexate level 5 × 10−8 m at 24 hr or >9 × 10−8 m at 48 hr; give leucovorin 100 mg/m2 q3hr until level drops to <10−8 m Megaloblastic anemia caused by enzyme deficiency (folate) • Adult/child: IV/IM 1 mg/day Pyrimethamine/trimethoprim toxicity prevention • Adult/child: PO/IV/IM 5-15 mg/day Advanced colorectal cancer L • Adult: IV 200 mg/m2, then 5-FU 370 mg/m2 or leucovorin 20 mg/m2, then 5-FU 425 mg/m2; give daily × 5 days q4-5wk HIGH ALERT
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• Adult/child: PO/IM/IV normal elim- ination given 6 hr after dose of metho- trexate (10 mg/m2) until methotrexate <5 × 10−8 m, CCr >50% above prior level, or methotrexate level 5 × 10−8 m at 24 hr or >9 × 10−8 m at 48 hr; give leucovorin 100 mg/m2 q3hr until level drops to <10−8 m Megaloblastic anemia caused by enzyme deficiency (folate)
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• Adult/child: IV/IM 1 mg/day Pyrimethamine/trimethoprim toxicity prevention
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• Adult/child: PO/IV/IM 5-15 mg/day Advanced colorectal cancer L
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• Adult: IV 200 mg/m2, then 5-FU 370 mg/m2 or leucovorin 20 mg/m2, then 5-FU 425 mg/m2; give daily × 5 days q4-5wk HIGH ALERT
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