Drug reference

Levodopa with carbidopa and entacapone

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 458, 459

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

STALEVO ® 100/25/200 Parkinson’s disease and end-of-dose motor fluctuations not adequately controlled with levodopa and dopa- decarboxylase inhibitor treatment ▶BY MOUTH ▶Adult: 1 tablet for each dose; maximum 10 tablets per day STALEVO ® 125/31.25/200 Parkinson’s disease and end-of-dose motor fluctuations not adequately controlled with levodopa and dopa- decarboxylase inhibitor treatment ▶BY MOUTH ▶Adult: 1 tablet for each dose; maximum 10 tablets per day STALEVO ® 150/37.5/200 Parkinson’s disease and end-of-dose motor fluctuations not adequately controlled with levodopa and dopa- decarboxylase inhibitor treatment ▶BY MOUTH ▶Adult: 1 tablet for each dose; maximum 10 tablets per day STALEVO ® 175/43.75/200 Parkinson’s disease and end-of-dose motor fluctuations not adequately controlled with levodopa and dopa- decarboxylase inhibitor treatment ▶BY MOUTH ▶Adult: 1 tablet for each dose; maximum 8 tablets per day STALEVO ® 200/50/200 Parkinson’s disease and end-of-dose motor fluctuations not adequately controlled with levodopa and dopa- decarboxylase inhibitor treatment ▶BY MOUTH ▶Adult: 1 tablet for each dose; maximum 7 tablets per day STALEVO ® 50/12.5/200 Parkinson’s disease and end-of-dose motor fluctuations not adequately controlled with levodopa and dopa- decarboxylase inhibitor treatment ▶BY MOUTH ▶Adult: 1 tablet for each dose; maximum 10 tablets per day STALEVO ® 75/18.75/200 Parkinson’s disease and end-of-dose motor fluctuations not adequately controlled with levodopa and dopa- decarboxylase inhibitor treatment ▶BY MOUTH ▶Adult: 1 tablet for each dose; maximum 10 tablets per day

PDF page 458

Prescribing And Dispensing Information

Patients receiving standard-release co-careldopa or co-beneldopa alone, initiate Stalevo ® at a dose that provides similar (or slightly lower) amount of levodopa. Patients with dyskinesia or receiving more than 800 mg levodopa daily, introduce entacapone before transferring to Stalevo ® (levodopa dose may need to be reduced by 10–30% initially). Patients receiving entacapone and standard-release co- careldopa or co-beneldopa, initiate Stalevo ® at a dose that provides similar (or slightly higher) amount of levodopa.

PDF pages 458, 459

Safety

Interactions

→Appendix 1: carbidopa. entacapone. levodopa

PDF page 458

Dose and formulations

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Tablet CAUTIONARY AND ADVISORY LABELS 10, 14(urine reddish-brown), ▶Stalevo (Orion Pharma (UK) Ltd) Carbidopa 25 mg, Levodopa 100 mg, Entacapone 200 mg Stalevo 100mg/25mg/200mg tablets | 30 tablet P £20.79 DT = £20.79 | 100 tablet P £69.31 DT = £69.31 Carbidopa 18.75 mg, Levodopa 75 mg, Entacapone 200 mg Stalevo 75mg/18.75mg/200mg tablets | 30 tablet P £20.79 DT = £20.79 | 100 tablet P £69.31 DT = £69.31 Carbidopa 37.5 mg, Levodopa 150 mg, Entacapone 200 mg Stalevo 150mg/37.5mg/200mg tablets | 30 tablet P £20.79 DT = £20.79 | 100 tablet P £69.31 DT = £69.31 Carbidopa 12.5 mg, Levodopa 50 mg, Entacapone 200 mg Stalevo 50mg/12.5mg/200mg tablets | 30 tablet P £20.79 DT = £20.79 | 100 tablet P £69.31 DT = £69.31 Carbidopa 31.25 mg, Levodopa 125 mg, Entacapone 200 mg Stalevo 125mg/31.25mg/200mg tablets | 30 tablet P £20.79 DT = £20.79 | 100 tablet P £69.31 DT = £69.31 Carbidopa 43.75 mg, Levodopa 175 mg, Entacapone 200 mg Stalevo 175mg/43.75mg/200mg tablets | 30 tablet P £20.79 DT = £20.79 | 100 tablet P £69.31 DT = £69.31 Carbidopa 50 mg, Entacapone 200 mg, Levodopa 200 mg Stalevo 200mg/50mg/200mg tablets | 30 tablet P £20.79 DT = £20.79 | 100 tablet P £69.31 DT = £69.31 DOPAMINERGIC DRUGS › DOPAMINE RECEPTOR AGONISTS

PDF page 459

Clinical care

Patient And Carer Advice

Driving and skilled tasks Sudden onset of sleep Excessive daytime sleepiness and sudden onset of sleep can occur with carbidopa with entacapone and levodopa. Patients starting treatment with these drugs should be warned of the risk and of the need to exercise caution when driving or operating machinery. Those who have experienced excessive sedation or sudden onset of sleep should refrain from driving or operating machines until these effects have stopped occurring. Management of excessive daytime sleepiness should focus on the identiﬁcation of an underlying cause, such as depression or concomitant medication. Patients should be counselled on improving sleep behaviour.

PDF page 459

Dose text by age group

Adult

1 tablet for each dose; maximum 10 tablets per

First-line fragment. Read the complete Indications and Dose section above.

PDF page 458

Adult

1 tablet for each dose; maximum 10 tablets per

First-line fragment. Read the complete Indications and Dose section above.

PDF page 458

Adult

1 tablet for each dose; maximum 10 tablets per

First-line fragment. Read the complete Indications and Dose section above.

PDF page 458

Adult

1 tablet for each dose; maximum 8 tablets per

First-line fragment. Read the complete Indications and Dose section above.

PDF page 458

Adult

1 tablet for each dose; maximum 7 tablets per

First-line fragment. Read the complete Indications and Dose section above.

PDF page 458

Adult

1 tablet for each dose; maximum 10 tablets per

First-line fragment. Read the complete Indications and Dose section above.

PDF page 458

Adult

1 tablet for each dose; maximum 10 tablets per

First-line fragment. Read the complete Indications and Dose section above.

PDF page 458

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

Levodopa with carbidopa and entacapone

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 458, 459

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

PDF page 458

Prescribing And Dispensing Information

PDF pages 458, 459

Safety

Interactions

→Appendix 1: carbidopa. entacapone. levodopa

PDF page 458

Dose and formulations

Medicinal Forms

PDF page 459

Clinical care

Patient And Carer Advice

PDF page 459

Dose text by age group

Adult

1 tablet for each dose; maximum 10 tablets per

First-line fragment. Read the complete Indications and Dose section above.

PDF page 458

Adult

1 tablet for each dose; maximum 10 tablets per

First-line fragment. Read the complete Indications and Dose section above.

PDF page 458

Adult

1 tablet for each dose; maximum 10 tablets per

First-line fragment. Read the complete Indications and Dose section above.

PDF page 458

Adult

1 tablet for each dose; maximum 8 tablets per

First-line fragment. Read the complete Indications and Dose section above.

PDF page 458

Adult

1 tablet for each dose; maximum 7 tablets per

First-line fragment. Read the complete Indications and Dose section above.

PDF page 458

Adult

1 tablet for each dose; maximum 10 tablets per

First-line fragment. Read the complete Indications and Dose section above.

PDF page 458

Adult

1 tablet for each dose; maximum 10 tablets per

First-line fragment. Read the complete Indications and Dose section above.

PDF page 458

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.