Drug Action
Levofolinic acid is an isomer of folinic acid.
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Drug reference
Levofolinic acid is an isomer of folinic acid.
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Prevention of methotrexate-induced adverse effects ▶BY INTRAMUSCULAR INJECTION, OR BY INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION ▶Adult: Usual dose 7.5 mg every 6 hours for 10 doses, usually started 12–24 hours after beginning of methotrexate infusion Suspected methotrexate overdosage ▶BY INTRAVENOUS INFUSION, OR BY INTRAVENOUS INJECTION ▶Adult: Initial dose at least 50% of the dose of methotrexate, intravenous infusion to be administered at a maximum rate of 160 mg/minute, consult poisons information centres for advice on continuing management Adjunct to fluorouracil in colorectal cancer ▶BY SLOW INTRAVENOUS INJECTION ▶Adult: (consult product literature)
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Intrathecal injection
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Avoid simultaneous administration of methotrexate. not indicated for pernicious anaemia or other megaloblastic anaemias caused by vitamin B12 deficiency
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→Appendix 1: folates
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▶Common or very common Dehydration. diarrhoea. mucosal toxicity. nausea. vomiting ▶Uncommon Fever ▶Rare or very rare Agitation (with high doses). depression (with high doses). epilepsy exacerbated. gastrointestinal disorder. insomnia (with high doses). urticaria
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Not known to be harmful; benefit outweighs risk.
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Presence in milk unknown but benefit outweighs risk.
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There can be variation in the licensing of different medicines containing the same drug. Solution for injection ▶Levofolinic acid (Non-proprietary) Levofolinic acid (as Disodium levofolinate) 50 mg per Immune system and malignant disease 1 ml Levofolinic acid 50mg/1ml solution for injection vials | 1 vial P £24.70 (Hospital only) Levofolinic acid 200mg/4ml solution for injection vials | 1 vial P £80.40 (Hospital only) ▶Isovorin (Pfizer Ltd) Levofolinic acid (as Calcium levofolinate) 10 mg per 1 ml Isovorin 175mg/17.5ml solution for injection vials | 1 vial P £81.33 (Hospital only) Isovorin 25mg/2.5ml solution for injection vials | 1 vial P £11.62 (Hospital only) 3.1a Hyperuricaemia associated with cytotoxic drugs Other drugs used for Hyperuricaemia associated with cytotoxic drugs Allopurinol, p. 1183. Febuxostat, p. 1184 DETOXIFYING DRUGS › URATE OXIDASES
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Usual dose 7.5 mg every 6 hours for 10 doses,
First-line fragment. Read the complete Indications and Dose section above.
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Initial dose at least 50% of the dose of
First-line fragment. Read the complete Indications and Dose section above.
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(consult product literature)
First-line fragment. Read the complete Indications and Dose section above.
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