Names and pronunciation
(lye-oh-thye′roe-neen) Cytomel, Triostat
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Drug reference
(lye-oh-thye′roe-neen) Cytomel, Triostat
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Func. class.: Thyroid hormone
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Chem. class.: Synthetic T3
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Do not confuse: liothyroxine/levothyroxine
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USES: Hypothyroidism, myxedema coma, thyroid hormone replacement, congenital hypothyroidism, nontoxic goiter, T3 suppression test
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CONTRAINDICATIONS: Adrenal insufficiency, MI, thyrotoxicosis, untreated hypertension
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Black Box Warning: Obesity treatment
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DOSAGE AND ROUTES • Adult: PO 25 mcg/day, increase by 12.5-25 mcg q1-2wk until desired re- sponse, maintenance dose 25-75 mcg/ day, max 100 mcg/day • Geriatric: PO 5 mcg/day, increase by 5 mcg/day q1-2wk, maintenance 25-75 mcg/day Congenital hypothyroidism • Child >3 yr: PO 50-100 mcg/day • Child <3 yr: PO 5 mcg/day, increase by 5 mcg q3-4days titrated to response, in- fant maintenance 20 mcg/day; 1-3 yr 50 mcg/day Myxedema, severe hypothyroidism • Adult: PO 25-50 mcg, then may in- crease by 5-10 mcg q1-2wk; mainte- nance dose 50-100 mcg/day Myxedema coma/precoma • Adult: IV 25-50 mcg initially, 5 mcg in geriatric patients, 10-20 mcg with car- diac disease; give doses q4-12hr Nontoxic goiter • Adult: PO 5 mcg/day, increase by 12.5-25 mcg q1-2wk; maintenance dose 75 mcg/day Suppression test • Adult: PO 75-100 mcg/day × 1 wk; radioactive 131I given before and after 1-wk dose
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Available forms: Tabs 5, 25, 50 mcg; injection 10 mcg/mL/vial HIGH ALERT
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• Geriatric: PO 5 mcg/day, increase by 5 mcg/day q1-2wk, maintenance 25-75 mcg/day Congenital hypothyroidism
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