Therapeutic Action
Antiretrovirals, HIV protease inhibitors
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Drug reference
Antiretrovirals, HIV protease inhibitors
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HIV infection, in combination with other antiretrovirals
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Do not administer to patients with severe hepatic impairment or hypokalaemia. Do not combine with rifampicin, replace with rifabutin. If rifabutin is not available and LPV/r is essential, adjust the dose: child: increase the dose of RTV to obtain a one-to-one (1:1) LPV/r ratio; adult: double the dose (800/200 mg 2 times daily). Administer with caution and monitor use in patients with haemophilia (increased bleeding) or mild to moderate hepatic impairment. May cause: gastrointestinal disturbances (mainly diarrhoea), skin rash, fatigue, headache, insomnia, paraesthesia, muscle pain hyperglycaemia, conduction disorders, hyperlipidaemia, lipodystrophy; hepatic and pancreatic disorders; in this event, stop treatment immediately. Administer with caution and monitor combination with drugs that prolong the QT interval (amiodarone, co-artemether, mefloquine, quinine, haloperidol, etc.). LPV/r reduces the efficacy of implants and oral contraceptives: use injectable medroxyprogesterone or an intrauterine device. Pregnancy: no contra-indication
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40 mg lopinavir/10 mg ritonavir sachet of granules 100 mg lopinavir/25 mg ritonavir film coated tablet
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The daily dose is administered in 2 divided doses. Child 2 weeks and over: Daily dose Weight 40/10 mg granules 100/25 mg tablet LPV/r 3 to < 6 kg 160/40 mg 2 sachets x 2 – 6 to < 10 kg 240/60 mg 3 sachets x 2 – 10 to < 14 kg 320/80 mg 4 sachets x 2 – 14 to < 20 kg 400/100 mg 5 sachets x 2 2 tab x 2 20 to < 25 kg 400/100 mg – 2 tab x 2 25 to < 35 kg 600/150 mg – 3 tab x 2 ≥ 35 kg 800/200 mg – 4 tab x 2 In children 10 to < 14 kg who can swallow the tablets whole, administer two 100/25 mg tablets in the morning and one 100/25 mg tablet in the evening (daily dose: 300/75 mg). In children on nevirapine or efavirenz: increase the dose of LPV/r according to manufacturer's instructions. Adult: 400/100 mg (4 tablets) 2 times daily (daily dose: 800/200 mg) In adult on nevirapine or efavirenz: 500/125 mg (5 tablets) 2 times daily (daily dose: 1000/250 mg)
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Depending on the efficacy and tolerance of lopinavir and ritonavir.
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Do not cut, crush or chew tablets. Pour granules into a small amount of breast milk, water or soft foods and administer immediately (within 2 hours of preparation max.).
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– – Below 25 °C
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500/125 mg (5 tablets) 2 times daily (daily dose: 1000/250 mg)
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