Drug reference
Insomnia (short-term use) ▶BY MOUTH ▶Adult: 1 mg once daily, then increased to 1.5–2 mg once daily if required, dose to be taken at bedtime, for debilitated patients, use elderly dose ▶Elderly: 0.5–1 mg once daily, dose to be taken at bedtime
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Respiratory depression
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Acute porphyrias p. 1120. hypoalbuminaemia. muscle weakness CAUTIONS, FURTHER INFORMATION ▶Paradoxical effects A paradoxical increase in hostility and aggression may be reported by patients taking benzodiazepines. The effects range from talkativeness and excitement to aggressive and antisocial acts. Adjustment of the dose (up or down) sometimes attenuates the impulses. Increased anxiety and perceptual disorders are other paradoxical effects.
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→Appendix 1: loprazolam
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Adjustment disorder. cognitive disorder. muscle tone decreased. speech disorder
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Benzodiazepines are present in milk, and should be avoided if possible during breast-feeding.
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Dose adjustments Start with small doses in severe impairment.
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There can be variation in the licensing of different medicines containing the same drug. Tablet CAUTIONARY AND ADVISORY LABELS 19 ▶Loprazolam (Non-proprietary) Loprazolam (as Loprazolam mesilate) 1 mg Loprazolam 1mg tablets | 28 tablet P £18.00–£27.00 DT = £22.50 d eiiii F 359
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1 mg once daily, then increased to 1.5–2 mg
First-line fragment. Read the complete Indications and Dose section above.
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