Drug reference
Symptomatic relief of allergy such as hay fever, chronic idiopathic urticaria ▶BY MOUTH ▶Child 2–11 years (body-weight up to 31 kg): 5 mg once daily ▶Child 2–11 years (body-weight 31 kg and above): 10 mg once daily ▶Child 12–17 years: 10 mg once daily ▶Adult: 10 mg once daily
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→Appendix 1: antihistamines, non- sedating
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▶Common or very common Drowsiness. nervousness (in children) ▶Uncommon Appetite increased. headache (very common in children). insomnia ▶Rare or very rare Alopecia. angioedema. dizziness. dry mouth. fatigue (very common in children). gastritis. hepatic function abnormal. nausea. palpitations. rash. seizure. tachycardia SIDE-EFFECTS, FURTHER INFORMATION Non-sedating antihistamines such as loratadine cause less sedation and psychomotor impairment than the older antihistamines, but can still occur; sedation is generally minimal. This is because non-sedating antihistamines penetrate the blood brain barrier to a much lesser extent.
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Most manufacturers of antihistamines advise avoiding their use during pregnancy; however, there is no evidence of teratogenicity.
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Most antihistamines are present in breast milk in varying amounts; although not known to be harmful, most manufacturers advise avoiding their use in mothers who are breast-feeding.
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Manufacturer advises caution in severe impairment (risk of increased exposure). Dose adjustments Manufacturer advises initial dose reduction to alternate days in severe impairment.
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There can be variation in the licensing of different medicines containing the same drug. Oral solution EXCIPIENTS: May contain Propylene glycol ▶Loratadine (Non-proprietary) Loratadine 1 mg per 1 ml Loratadine 5mg/5ml oral solution | 100 ml P £1.90 DT = £1.90 Loratadine 5mg/5ml oral solution sugar-free | 100 ml P £2.85 Tablet ▶Loratadine (Non-proprietary) Loratadine 10 mg Loratadine 10mg tablets | 30 tablet P s DT = £0.95 ▶Clarityn (Loratadine) (Bayer Plc) Loratadine 10 mg Clarityn Allergy 10mg tablets | 60 tablet p £8.85
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Medicines for Children leaflet: Loratadine for allergy symptoms www.medicinesforchildren.org.uk/loratadine-allergy-symptoms Driving and skilled tasks Although drowsiness is rare, nevertheless patients and their carers should be advised that it can occur and may affect performance of skilled tasks (e.g. cycling or driving); alcohol should be avoided. l PROFESSION SPECIFIC INFORMATION Dental practitioners’ formulary Loratadine 10 mg tablets may be prescribed. Loratadine syrup 5 mg/5 mL may be prescribed.
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5 mg once daily
First-line fragment. Read the complete Indications and Dose section above.
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10 mg
First-line fragment. Read the complete Indications and Dose section above.
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10 mg once daily
First-line fragment. Read the complete Indications and Dose section above.
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