Drug reference
Insomnia (short-term use) ▶BY MOUTH ▶Adult: 0.5–1.5 mg once daily, dose to be taken at bedtime, for debilitated patients, use elderly dose ▶Elderly: 500 micrograms once daily, dose to be taken at bedtime
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Not for use alone to treat insomnia associated with depression. respiratory depression
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Acute porphyrias p. 1120. hypoalbuminaemia. muscle weakness CAUTIONS, FURTHER INFORMATION ▶Paradoxical effects A paradoxical increase in hostility and aggression may be reported by patients taking benzodiazepines. The effects range from talkativeness and excitement to aggressive and antisocial acts. Adjustment of the dose (up or down) sometimes attenuates the impulses. Increased anxiety and perceptual disorders are other paradoxical effects.
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→Appendix 1: lormetazepam
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▶Common or very common Asthenia ▶Rare or very rare Agranulocytosis. allergic dermatitis. apnoea. appetite change. coma. constipation. disinhibition. extrapyramidal symptoms. hyponatraemia. hypothermia. leucopenia. memory loss. obstructive pulmonary disease exacerbated. pancytopenia. saliva altered. sexual dysfunction. SIADH. speech slurred. thrombocytopenia ▶Frequency not known Suicide attempt
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Benzodiazepines are present in milk, and should be avoided if possible during breast-feeding.
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Dose adjustments Start with small doses in severe impairment.
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There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: oral suspension Tablet CAUTIONARY AND ADVISORY LABELS 19 ▶Lormetazepam (Non-proprietary) Lormetazepam 500 microgram Lormetazepam 500microgram tablets | 30 tablet P £64.17 DT = £19.07 d Lormetazepam 1 mg Lormetazepam 1mg tablets | 30 tablet P £17.78 DT = £17.78 d eiiii F 359
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0.5–1.5 mg once daily, dose to be taken at
First-line fragment. Read the complete Indications and Dose section above.
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