Indications And Dose
Diabetic nephropathy in type 2 diabetes mellitus ▶BY MOUTH ▶Adult 18–75 years: Initially 50 mg once daily for several weeks, then increased if necessary to 100 mg once daily ▶Adult 76 years and over: Initially 25 mg once daily for several weeks, then increased if necessary to 100 mg continued → once daily Chronic heart failure when ACE inhibitors are unsuitable or contra-indicated ▶BY MOUTH ▶Adult: Initially 12.5 mg once daily, increased if Cardiovascular system tolerated to up to 150 mg once daily, doses to be increased at weekly intervals Hypertension (including reduction of stroke risk in hypertension with left ventricular hypertrophy) ▶BY MOUTH ▶Adult 18–75 years: Initially 50 mg once daily for several weeks, then increased if necessary to 100 mg once daily ▶Adult 76 years and over: Initially 25 mg once daily for several weeks, then increased if necessary to 100 mg once daily Hypertension with intravascular volume depletion ▶BY MOUTH ▶Adult 18–75 years: Initially 25 mg once daily for several weeks, then increased if necessary up to 100 mg once daily
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