Drug reference

Macrogol 3350 with anhydrous sodium sulfate, potassium chloride, sodium bicarbonate and sodium chloride

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 77, 78

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

Bowel cleansing before radiological examination, colonoscopy, or surgery ▶INITIALLY BY MOUTH ▶Adult: Initially 2 litres daily for 2 doses: ﬁrst dose of reconstituted solution taken on the evening before procedure and the second dose on the morning of procedure, alternatively (by mouth) initially 250 mL every 10–15 minutes, reconstituted solution to be administered, alternatively (by nasogastric tube) initially 20–30 mL/minute, starting on the day before procedure until 4 litres have been consumed

PDF page 77

Contra Indications

Acute severe colitis. gastric retention. gastrointestinal obstruction. gastrointestinal perforation. toxic megacolon

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Cautions

Colitis. debilitated patients. ﬂuid and electrolyte disturbances. heart failure (avoid if moderate to severe). hypovolaemia (should be corrected before administration of bowel cleansing preparations). impaired gag reﬂex or possibility of regurgitation or aspiration

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Prescribing And Dispensing Information

Each Klean- Prep ® sachet provides Na+ 125 mmol, K+ 10 mmol, Cl- 35 mmol and HCO3 - 20mmol when reconstituted with 1 litre of water.

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Safety

Interactions

→Appendix 1: bowel cleansing preparations

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Side Effects

Angioedema. arrhythmia. chills. confusion Gastro-intestinal system . dehydration. dizziness. dyspnoea. electrolyte imbalance . fever. ﬂatulence. gastrointestinal discomfort. headache. malaise. nausea. palpitations. seizure. skin reactions. thirst. vomiting SIDE-EFFECTS, FURTHER INFORMATION Abdominal pain is usually transient and can be reduced by taking preparation more slowly.

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Pregnancy

Manufacturers advise use only if essential— no information available.

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Breast Feeding

Manufacturers advise use only if essential—no information available.

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Monitoring Requirements

Renal function should be measured before starting treatment in patients at risk of ﬂuid and electrolyte disturbances.

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Dose and formulations

Directions For Administration

1 sachet should be reconstituted with 1 litre of water. Flavouring such as clear fruit cordials may be added if required. After reconstitution the solution should be kept in a refrigerator and discarded if unused after 24 hours.

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Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Powder CAUTIONARY AND ADVISORY LABELS 10, 13 EXCIPIENTS: May contain Aspartame ELECTROLYTES: May contain Bicarbonate, chloride, potassium, sodium ▶Klean-Prep (Forum Health Products Ltd) Potassium chloride 742.5 mg, Sodium chloride 1.465 gram, Sodium bicarbonate 1.685 gram, Sodium sulfate anhydrous 5.685 gram, Polyethylene glycol 3350 59 gram Klean-Prep oral powder 69g sachets sugar-free | 4 sachet p £10.48 LAXATIVES › STIMULANT LAXATIVES

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Clinical care

Patient And Carer Advice

Solid food should not be taken for 2 hours before starting treatment. Adequate hydration should be maintained during treatment. Treatment can be stopped if bowel motions become watery and clear.

PDF page 78

Dose text by age group

Adult

Initially 2 litres daily for 2 doses: ﬁrst dose of

First-line fragment. Read the complete Indications and Dose section above.

PDF page 77

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

Macrogol 3350 with anhydrous sodium sulfate, potassium chloride, sodium bicarbonate and sodium chloride

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 77, 78

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

PDF page 77

Contra Indications

Acute severe colitis. gastric retention. gastrointestinal obstruction. gastrointestinal perforation. toxic megacolon

PDF page 77

Cautions

PDF page 77

Prescribing And Dispensing Information

Each Klean- Prep ® sachet provides Na+ 125 mmol, K+ 10 mmol, Cl- 35 mmol and HCO3 - 20mmol when reconstituted with 1 litre of water.

PDF page 78

Safety

Interactions

→Appendix 1: bowel cleansing preparations

PDF page 78

Side Effects

PDF page 78

Pregnancy

Manufacturers advise use only if essential— no information available.

PDF page 78

Breast Feeding

Manufacturers advise use only if essential—no information available.

PDF page 78

Monitoring Requirements

Renal function should be measured before starting treatment in patients at risk of ﬂuid and electrolyte disturbances.

PDF page 78

Dose and formulations

Directions For Administration

PDF page 78

Medicinal Forms

PDF page 78

Clinical care

Patient And Carer Advice

Solid food should not be taken for 2 hours before starting treatment. Adequate hydration should be maintained during treatment. Treatment can be stopped if bowel motions become watery and clear.

PDF page 78

Dose text by age group

Adult

Initially 2 litres daily for 2 doses: ﬁrst dose of

First-line fragment. Read the complete Indications and Dose section above.

PDF page 77

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.