Drug Action
Maraviroc is an antagonist of the CCR5 chemokine receptor.
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Drug reference
Maraviroc is an antagonist of the CCR5 chemokine receptor.
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CCR5-tropic HIV infection in combination with other Infection antiretroviral drugs in patients previously treated with antiretrovirals ▶BY MOUTH ▶Adult: 300 mg twice daily
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Cardiovascular disease
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Scottish Medicines Consortium (SMC) decisions SMC No. 458/08 The Scottish Medicines Consortium has advised (October 2008) that maraviroc (Celsentri ®) is not recommended for use within NHS Scotland as the economic case was not demonstrated.
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→Appendix 1: maraviroc
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▶Common or very common Abdominal pain. anaemia. appetite decreased. asthenia. depression. diarrhoea. flatulence. headache. insomnia. nausea. rash ▶Uncommon Hyperbilirubinaemia. increased risk of infection. myopathy. postural hypotension. proteinuria. renal failure. seizure ▶Rare or very rare Angina pectoris. granulocytopenia. hepatic disorders. metastases. neoplasms. pancytopenia. severe cutaneous adverse reactions (SCARs) ▶Frequency not known Fever. hypersensitivity. immune reconstitution inflammatory syndrome. organ dysfunction . osteonecrosis SIDE-EFFECTS, FURTHER INFORMATION Osteonecrosis Osteonecrosis has been reported in patients with advanced HIV disease or following long-term exposure to combination antiretroviral therapy. Hepatotoxicity Manufacturer advises consider discontinuation if signs or symptoms of acute hepatitis, or increased liver transaminases with systemic symptoms of hypersensitivity occur.
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Manufacturer advises use only if potential benefit outweighs risk—toxicity in animal studies.
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Manufacturer advises caution in impairment and in patients with chronic hepatitis (increased risk of hepatic side-effects; limited information available).
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If eGFR less than 80 mL/minute/1.73 m2, consult product literature.
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There can be variation in the licensing of different medicines containing the same drug. Tablet ▶Celsentri (ViiV Healthcare UK Ltd) Maraviroc 25 mg Celsentri 25mg tablets | 120 tablet P £147.09 DT = £147.09 Maraviroc 75 mg Celsentri 75mg tablets | 120 tablet P £441.27 DT = £441.27 Maraviroc 150 mg Celsentri 150mg tablets | 60 tablet P £519.14 DT = £519.14 Maraviroc 300 mg Celsentri 300mg tablets | 60 tablet P £519.14 DT = £519.14 PHARMACOKINETIC ENHANCERS
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300 mg twice daily
First-line fragment. Read the complete Indications and Dose section above.
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