Drug reference
Cytotoxic induced urothelial toxicity ▶BY MOUTH, OR BY INTRAVENOUS INJECTION ▶Adult: Dose to be calculated according to oxazaphosphorine (cyclophosphamide or ifosfamide) treatment (consult product literature)
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Contra-indicated if history of hypersensitivity to thiol-containing compounds.
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▶Common or very common Appetite decreased. arthralgia. asthenia. chest pain. chills. concentration impaired. conjunctivitis. constipation. cough. dehydration. diarrhoea. dizziness. drowsiness. dry mouth. dyspnoea. dysuria. fever. flatulence. flushing. gastrointestinal discomfort. haemorrhage. headache. hyperhidrosis. influenza like illness. laryngeal discomfort. lymphadenopathy. malaise. myalgia. nasal congestion. nausea. oral irritation. pain. palpitations. respiratory disorders. sensation abnormal. skin reactions. sleep disorders. syncope. vision disorders. vomiting ▶Frequency not known Acute kidney injury. angioedema. drug reaction with eosinophilia and systemic symptoms (DRESS). hypotension. hypoxia. oedema. tachycardia. ulcer. vulvovaginal rash
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Not known to be harmful. See also Pregnancy and reproductive function in Cytotoxic drugs p. 938. l EFFECT ON LABORATORY TESTS False positive urinary ketones. False positive or false negative urinary erythrocytes.
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For oral administration of the injection, contents of ampoule are taken in a flavoured drink such as orange juice or cola which may be stored in a refrigerator for up to 24 hours in a sealed container.
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There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: oral solution Solution for injection ▶Mesna (Non-proprietary) Mesna 100 mg per 1 ml Mesna 1g/10ml solution for injection ampoules | 15 ampoule P £441.15–£447.15 Mesna 400mg/4ml solution for injection ampoules | 5 ampoule P £17.00 | 15 ampoule P £201.15 Tablet ▶Mesna (Non-proprietary) Mesna 400 mg Mesna 400mg tablets | 10 tablet P £134.30 Mesna 600 mg Mesna 600mg tablets | 10 tablet P £190.60 VITAMINS AND TRACE ELEMENTS › FOLATES
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Dose to be calculated according to
First-line fragment. Read the complete Indications and Dose section above.
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