Drug reference
Prophylaxis and long-term treatment of chronic or recurrent uncomplicated lower urinary-tract infections ▶BY MOUTH ▶Adult: 1 g every 12 hours Prophylaxis and long-term treatment of chronic or recurrent uncomplicated lower urinary-tract infections in patients with catheters ▶BY MOUTH ▶Adult: 1 g every 8–12 hours
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Gout. metabolic acidosis. severe dehydration
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→Appendix 1: methenamine
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▶Uncommon Epigastric discomfort. skin reactions
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There is inadequate evidence of safety, but it has been in wide use for many years without apparent ill consequence, however, manufacturer advises it is preferable to avoid.
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Amount too small to be harmful.
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Manufacturer advises avoid.
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Avoid if eGFR less than 10 mL/minute/1.73 m2—risk of hippurate crystalluria. l EFFECT ON LABORATORY TESTS False results for urinary steroids, catecholamines and 5-hydroxyindole acetic acid can occur. l LESS SUITABLE FOR PRESCRIBING Methenamine (hexamine) hippurate should not generally be used because it requires an acidic urine for its antimicrobial activity and it is ineffective for upper urinary-tract infections; it may, however, have a role in the prophylaxis and treatment of chronic or recurrent uncomplicated lower urinary-tract infections. It is considered less suitable for prescribing.
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There can be variation in the licensing of different medicines containing the same drug. Tablet CAUTIONARY AND ADVISORY LABELS 9 ▶Methenamine hippurate (Non-proprietary) Methenamine hippurate 1 gram Methenamine hippurate 1g tablets | 60 tablet p £19.74–£23.68 DT = £19.74 ▶Hiprex (Mylan) Methenamine hippurate 1 gram Hiprex 1g tablets | 60 tablet p £19.74 DT = £19.74
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1 g every 12 hours
First-line fragment. Read the complete Indications and Dose section above.
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1 g every 8–12 hours
First-line fragment. Read the complete Indications and Dose section above.
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