Indications And Dose
Symptomatic anaemia associated with chronic kidney disease in patients on dialysis and not currently treated with erythropoietins ▶BY SUBCUTANEOUS INJECTION, OR BY INTRAVENOUS INJECTION Blood and nutrition ▶Adult: Initially 600 nanograms/kg every 2 weeks, subcutaneous route preferred in patients not on haemodialysis, dose to be adjusted according to response at intervals of at least 1 month, maintenance dose of double the previous fortnightly dose may be given once a month if haemoglobin concentration is above 10 g/100 mL, reduce dose by approximately 25% if rate of rise in haemoglobin concentration exceeds 2 g/100 mL in 1 month or if haemoglobin concentration is increasing or approaching 12 g/100 mL; if haemoglobin concentration continues to rise, despite dose reduction, suspend treatment until haemoglobin concentration decreases and then restart at a dose approximately 25% lower than the previous dose, dose may be increased by approximately 25% if the rate of rise in haemoglobin concentration is less than 1 g/100 mL over 1 month; further increases of approximately 25% may be made at monthly intervals until the individual target haemoglobin concentration is obtained Symptomatic anaemia associated with chronic kidney disease in patients not on dialysis and not currently treated with erythropoietins ▶INITIALLY BY SUBCUTANEOUS INJECTION ▶Adult: Initially 1.2 micrograms/kg every month, alternatively (by subcutaneous injection or by intravenous injection) initially 600 nanograms/kg every 2 weeks, subcutaneous route preferred in patients not on haemodialysis, dose to be adjusted according to response at intervals of at least 1 month, patients treated once every 2 weeks may be given a maintenance dose of double the previous fortnightly dose once a month if haemoglobin concentration is above 10 g/100 mL, reduce dose by approximately 25% if rate of rise in haemoglobin concentration exceeds 2 g/100 mL in 1 month or if haemoglobin concentration is increasing or approaching 12 g/100 mL; if haemoglobin concentration continues to rise, despite dose reduction, suspend treatment until haemoglobin concentration decreases and then restart at a dose approximately 25% lower than the previous dose, dose may be increased by approximately 25% if the rate of rise in haemoglobin concentration is less than 1 g/100 mL over 1 month; further increases of approximately 25% may be made at monthly intervals until the individual target haemoglobin concentration is obtained Symptomatic anaemia associated with chronic kidney disease in patients currently treated with erythropoietins ▶BY SUBCUTANEOUS INJECTION, OR BY INTRAVENOUS INJECTION ▶Adult: (consult product literature)
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