Indications And Dose
Attention deficit hyperactivity disorder (initiated under specialist supervision) ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Child 6–17 years: Initially 5 mg 1–2 times a day, increased in steps of 5–10 mg daily if required, at weekly intervals, increased if necessary up to 60 mg daily in 2–3 divided doses, increased if necessary up to 2.1 mg/kg daily in 2–3 divided doses, the licensed maximum dose is 60 mg daily in 2–3 doses, higher dose (up to a maximum of 90 mg daily) under the direction of a specialist, discontinue if no response after 1 month, if effect wears off in evening (with rebound hyperactivity) a dose at bedtime may be appropriate (establish need with trial bedtime dose). Treatment may be started using a modified-release preparation ▶Adult: Initially 5 mg 2–3 times a day, dose is increased if necessary at weekly intervals according to response, increased if necessary up to 100 mg daily in 2–3 divided doses, if effect wears off in evening (with rebound continued → hyperactivity) a dose at bedtime may be appropriate (establish need with trial bedtime dose). Treatment may be started using a modified-release preparation Narcolepsy ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Adult: 10–60 mg daily in divided doses; usual dose 20–30 mg daily in divided doses, dose to be taken Nervous system before meals DOSE EQUIVALENCE AND CONVERSION ▶When switching from immediate-release preparations to modified-release preparations—consult product literature. CONCERTA ® XL Attention deficit hyperactivity disorder ▶BY MOUTH ▶Child 6–17 years: Initially 18 mg once daily, dose to be taken in the morning, increased in steps of 18 mg every week, adjusted according to response; increased if necessary up to 2.1 mg/kg daily, licensed max. dose is 54 mg once daily, to be increased to higher dose only under direction of specialist; discontinue if no response after 1 month; maximum 108 mg per day ▶Adult: Initially 18 mg once daily, dose to be taken in the morning; adjusted at weekly intervals according to response; maximum 108 mg per day DOSE EQUIVALENCE AND CONVERSION ▶Total daily dose of 15 mg of standard-release formulation is considered equivalent to Concerta ® XL 18 mg once daily. DELMOSART ® PROLONGED-RELEASE TABLET Attention deficit hyperactivity disorder (under expert supervision) ▶BY MOUTH ▶Child 6–17 years: Initially 18 mg once daily, dose to be taken in the morning, then increased in steps of 18 mg every week if required, discontinue if no response after1 month; maximum 54 mg per day ▶Adult: Initially 18 mg once daily, dose to be taken in the morning, then increased in steps of 18 mg every week if required, discontinue if no response after 1 month; maximum 54 mg per day DOSE EQUIVALENCE AND CONVERSION ▶Total daily dose of 15 mg of standard-release formulation is considered equivalent to Delmosart ® 18 mg once daily. EQUASYM ® XL Attention deficit hyperactivity disorder ▶BY MOUTH ▶Child 6–17 years: Initially 10 mg once daily, dose to be taken in the morning before breakfast; increased gradually at weekly intervals if necessary; increased if necessary up to 2.1 mg/kg daily, licensed max. dose is 60 mg daily, to be increased to higher dose only under direction of specialist; discontinue if no response after 1 month; maximum 90 mg per day ▶Adult: Initially 10 mg once daily, dose to be taken in the morning before breakfast; increased gradually at weekly intervals if necessary; maximum 100 mg per day MEDIKINET ® XL Attention deficit hyperactivity disorder ▶BY MOUTH ▶Child 6–17 years: Initially 10 mg once daily, dose to be taken in the morning with breakfast; adjusted at weekly intervals according to response; increased if necessary up to 2.1 mg/kg daily, licensed max. dose is 60 mg daily, to be increased to higher dose only under direction of specialist; discontinue if no response after 1 month; maximum 90 mg per day ▶Adult: Initially 10 mg once daily, dose to be taken in the morning with breakfast; adjusted at weekly intervals according to response; maximum 100 mg per day XAGGITIN ® XL Attention deficit hyperactivity disorder (under expert supervision) ▶BY MOUTH ▶Child 6–17 years: Initially 18 mg once daily, dose to be taken in the morning, increased in steps of 18 mg every week, adjusted according to response, discontinue if no response after 1 month; maximum 54 mg per day ▶Adult: Initially 18 mg once daily, dose to be taken in the morning, increased in steps of 18 mg every week, adjusted according to response, discontinue if no response after 1 month; maximum 54 mg per day DOSE EQUIVALENCE AND CONVERSION ▶Total daily dose of 15 mg of standard-release formulation is considered equivalent to Xaggitin ® XL 18 mg once daily. l UNLICENSED USE Doses over 60 mg daily not licensed; doses of Concerta XL over 54 mg daily not licensed. Not licensed for use in narcolepsy. Not licensed for use in adults for attention deficit hyperactivity disorder.
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