Therapeutic Action
Antiemetic (dopamine antagonist)
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Drug reference
Antiemetic (dopamine antagonist)
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Prevention or symptomatic treatment of nausea and vomiting in adults
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Do not administer to children < 18 years or to patients with gastrointestinal haemorrhage, obstruction or perforation. Reduce the dose by half in patients with severe renal impairment. Administer with caution and monitor use in patients > 60 years and patients with epilepsy or Parkinson's disease. May cause: drowsiness, dizziness, confusion, extrapyramidal symptoms, seizures (especially in patients with epilepsy), allergic reactions, cardiac disorders (hypotension, bradycardia, cardiac arrest); neuroleptic malignant syndrome (unexplained hyperthermia with neuromuscular disorders), rare but requiring immediate treatment discontinuation. Do not combine with levodopa (antagonism). Avoid combination with CNS depressants (opioid analgesics, antipsychotics, sedatives, antidepressants, antihistamines, etc.) and antihypertensive drugs (increased risk of hypotension). Pregnancy: no contra-indication Breast-feeding: no contra-indication
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10 mg in 2 ml ampoule (5 mg/ml) for IM or slow IV injection (3 to 5 minutes)
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Adult: 10 mg every 8 hours if necessary
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Change to oral treatment as soon as possible.
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For postoperative nausea and vomiting in adults, efficacy of metoclopramide is limited: ondansetron is preferred.
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– Below 25 °C
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10 mg every 8 hours if necessary
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