Drug reference

Metoprolol tartrate

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 188, 189

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

Hypertension ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Adult: Initially 100 mg daily, increased if necessary to 200 mg daily in 1–2 divided doses, high doses are rarely required; maximum 400 mg per day ▶BY MOUTH USING MODIFIED-RELEASE MEDICINES ▶Adult: 200 mg once daily Angina ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Adult: 50–100 mg 2–3 times a day ▶BY MOUTH USING MODIFIED-RELEASE MEDICINES ▶Adult: 200–400 mg daily Arrhythmias ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Adult: Usual dose 50 mg 2–3 times a day, then increased if necessary up to 300 mg daily in divided doses ▶BY INTRAVENOUS INJECTION ▶Adult: Up to 5 mg, dose to be given at a rate of 1–2 mg/minute, then up to 5 mg after 5 minutes if required, total dose of 10–15 mg Migraine prophylaxis ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Adult: 100–200 mg daily in divided doses ▶BY MOUTH USING MODIFIED-RELEASE MEDICINES ▶Adult: 200 mg daily Hyperthyroidism (adjunct) ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Adult: 50 mg 4 times a day In surgery ▶BY SLOW INTRAVENOUS INJECTION ▶Adult: Initially 2–4 mg, given at induction or to control arrhythmias developing during anaesthesia, then 2 mg, repeated if necessary; maximum 10 mg per course Early intervention within 12 hours of infarction ▶INITIALLY BY INTRAVENOUS INJECTION ▶Adult: Initially 5 mg every 2 minutes, to a max. of 15 mg, followed by (by mouth) 50 mg every 6 hours for 48 hours, to be taken 15 minutes after intravenous injection; (by mouth) maintenance 200 mg daily in divided doses

PDF page 188

Safety

Interactions

→Appendix 1: beta blockers, selective

PDF page 188

Side Effects

GENERAL SIDE-EFFECTS ▶Common or very common Constipation. palpitations. postural disorders ▶Uncommon Chest pain. drowsiness. dystrophic skin lesion . hyperhidrosis. muscle cramps. oedema. skin reactions. weight increased ▶Rare or very rare Alopecia. arrhythmia. conjunctivitis. dry mouth. eye irritation. gangrene. hepatitis. rhinitis. sexual dysfunction. thrombocytopenia SPECIFIC SIDE-EFFECTS ▶Uncommon ▶With intravenous use Cardiogenic shock. concentration impaired ▶Rare or very rare ▶With intravenous use Anxiety. arthralgia. atrioventricular block exacerbated. memory loss. photosensitivity reaction . taste altered. tinnitus ▶With oral use Alertness decreased. arthritis. auditory disorder. personality disorder ▶Frequency not known ▶With oral use Peyronie’s disease. retroperitoneal ﬁbrosis

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Hepatic Impairment

Manufacturer advises caution in severe impairment (bioavailability may be increased in patients with liver cirrhosis). Dose adjustments Manufacturer advises consider dose reduction in severe impairment.

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Dose and formulations

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: capsule, oral suspension, oral solution Tablet CAUTIONARY AND ADVISORY LABELS 8 ▶Metoprolol tartrate (Non-proprietary) Metoprolol tartrate 50 mg Metoprolol 50mg tablets | 28 tablet P £4.35 DT = £3.63 | 56 tablet P £7.26 Metoprolol tartrate 100 mg Metoprolol 100mg tablets | 28 tablet P £4.62 DT = £3.46 | 56 tablet P £6.92 Solution for injection ▶Betaloc (Recordati Pharmaceuticals Ltd) Metoprolol tartrate 1 mg per 1 ml Betaloc I.V. 5mg/5ml solution for injection ampoules | 5 ampoule P £5.02 (Hospital only) eiiii F 159

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Dose text by age group

Adult

Initially 100 mg daily, increased if necessary to

First-line fragment. Read the complete Indications and Dose section above.

PDF page 188

Adult

200 mg once daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 188

Adult

50–100 mg 2–3 times a day

First-line fragment. Read the complete Indications and Dose section above.

PDF page 188

Adult

200–400 mg daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 188

Adult

Usual dose 50 mg 2–3 times a day, then

First-line fragment. Read the complete Indications and Dose section above.

PDF page 188

Adult

Up to 5 mg, dose to be given at a rate of

First-line fragment. Read the complete Indications and Dose section above.

PDF page 188

Adult

100–200 mg daily in divided doses

First-line fragment. Read the complete Indications and Dose section above.

PDF page 188

Adult

200 mg daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 188

Adult

50 mg 4 times a day

First-line fragment. Read the complete Indications and Dose section above.

PDF page 188

Adult

Initially 2–4 mg, given at induction or to control

First-line fragment. Read the complete Indications and Dose section above.

PDF page 188

Adult

Initially 5 mg every 2 minutes, to a max. of

First-line fragment. Read the complete Indications and Dose section above.

PDF page 188

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

Metoprolol tartrate

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 188, 189

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

PDF page 188

Safety

Interactions

→Appendix 1: beta blockers, selective

PDF page 188

Side Effects

PDF page 188

Hepatic Impairment

PDF page 189

Dose and formulations

Medicinal Forms

PDF page 189

Dose text by age group

Adult

Initially 100 mg daily, increased if necessary to

First-line fragment. Read the complete Indications and Dose section above.

PDF page 188

Adult

200 mg once daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 188

Adult

50–100 mg 2–3 times a day

First-line fragment. Read the complete Indications and Dose section above.

PDF page 188

Adult

200–400 mg daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 188

Adult

Usual dose 50 mg 2–3 times a day, then

First-line fragment. Read the complete Indications and Dose section above.

PDF page 188

Adult

Up to 5 mg, dose to be given at a rate of

First-line fragment. Read the complete Indications and Dose section above.

PDF page 188

Adult

100–200 mg daily in divided doses

First-line fragment. Read the complete Indications and Dose section above.

PDF page 188

Adult

200 mg daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 188

Adult

50 mg 4 times a day

First-line fragment. Read the complete Indications and Dose section above.

PDF page 188

Adult

Initially 2–4 mg, given at induction or to control

First-line fragment. Read the complete Indications and Dose section above.

PDF page 188

Adult

Initially 5 mg every 2 minutes, to a max. of

First-line fragment. Read the complete Indications and Dose section above.

PDF page 188

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.