Names and pronunciation
(met′-re-lep′-tin) Myalept
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Drug reference
(met′-re-lep′-tin) Myalept
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Func. class.: Hormone replacement- leptin receptor agonist
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USES: Complications caused by leptin deficiency in patients with congenital or acquired generalized lipodystrophy
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CONTRAINDICATIONS: Hyper- sensitivity
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Black Box Warning: Secondary malig- nancy, antimetreleptin antibodies
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DOSAGE AND ROUTES • Adult/adolescent/child >40 kg: SUB- CUT 2.5 mg/day (0.5 mL) initially, may increase or decrease dose by 1.25-2.5 mg/ day (0.25-0.5 mL) as needed, max 10 mg/ day (2 mL/day). Females: 5 mg/day (1 mL) initially; may increase or decrease dose by 1.25-2.5 mg/day (0.25-0.5 mL) as needed, max 10 mg/day (2 mL/day) • Adult/adolescent/child/neonate ≤40 kg: SUBCUT 0.06 mg/kg/day (0.012 mL/ kg) initially. Increase or decrease dose by 0.02 mg/kg/day (0.004 mL/kg) as needed, M max 0.13 mg/kg/day (0.026 mL/kg/day). Give daily at the same time every day
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Available forms: Powder for injection 11.3 mg
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• Adult/adolescent/child/neonate ≤40 kg: SUBCUT 0.06 mg/kg/day (0.012 mL/ kg) initially. Increase or decrease dose by 0.02 mg/kg/day (0.004 mL/kg) as needed, M max 0.13 mg/kg/day (0.026 mL/kg/day). Give daily at the same time every day
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