Therapeutic Action
Antiprotozoal, antibacterial (group of nitroimidazoles)
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Drug reference
Antiprotozoal, antibacterial (group of nitroimidazoles)
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Amoebiasis, giardiasis, trichomoniasis Bacterial vaginitis, infections due to anaerobic bacteria (e.g. Clostridium sp, Bacteroides sp, etc.)
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Do not administer to patients with hypersensitivity to metronidazole or another nitroimidazole (tinidazole, secnidazole, etc.). May cause: gastrointestinal disturbances; rarely: allergic reactions, brownish urine, headache, dizziness. Risk of antabuse reaction when combined with alcohol. Administer with caution in patients taking oral anticoagulants (risk of haemorrhage), lithium, phenytoin, ergometrine (increased plasma concentrations of these drugs). Reduce total daily dose to one third and give once daily to patients with severe hepatic impairment. Pregnancy: no contra-indication; divide into smaller doses, avoid prolonged use. Breast-feeding: significantly excreted in milk (risk of gastrointestinal disturbances in breastfed infants); divide into smaller doses, avoid prolonged use.
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250 mg and 500 mg tablets 200 mg/5 ml oral suspension
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Amoebiasis Child: 15 mg/kg 3 times daily Adult: 500 mg 3 times daily The treatment lasts 5 days in intestinal amoebiasis and 5 to 10 days in hepatic amoebiasis. Giardiasis Child: 30 mg/kg once daily for 3 days Adult: 2 g once daily for 3 days Trichomoniasis and bacterial vaginitis Adult: 2 g single dose In the event of trichomoniasis, also treat sexual partner. Infections due to anaerobic bacteria Child: 10 mg/kg 3 times daily Adult: 500 mg 3 times daily According to indication, metronidazole may be used in combination with other anti bacterials; treatment duration depends on indication.
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– Below 25 °C For the oral suspension: follow manufacturer’s instructions.
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500 mg 3 times daily
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2 g once daily for 3 days
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2 g single dose
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500 mg 3 times daily
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