Names and pronunciation
(met-roe-ni′da-zole) MetroCream, MetroGel, MetroGel Vaginal, MetroLotion, Noritate, Nuvessa, Rosasol , Rosadan, Vandazole
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Drug reference
(met-roe-ni′da-zole) MetroCream, MetroGel, MetroGel Vaginal, MetroLotion, Noritate, Nuvessa, Rosasol , Rosadan, Vandazole
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Func. class.: Antiprotozoal, antibacterial
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Chem. class.: Nitroimidazole
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ACTION: Antibacterial and antiproto- zoal activity may result from interacting with DNA
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USES: Acne rosacea, bacterial vaginosis
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CONTRAINDICATIONS: Hyper- sensitivity to this product or nitroimid- azoles, parabens Precautions: Hepatic disease, blood dyscrasias; CNS conditions (vaginal), children, pregnancy
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SIDE EFFECTS GU: Vaginitis, cervicitis GI: Nausea, vomiting, cramping INTEG: Redness, burning, dermatitis, rash, pruritus
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INTERACTIONS • Possible lithium toxicity (vaginal gel)
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DOSAGE AND ROUTES Acne rosacea • Adult: TOP apply to affected areas bid (0.75%) or daily (1%); adjust therapy based on response Bacterial vaginosis • Adult: VAG 1 applicatorful daily × 5 days
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Available forms: Topical cream 0.75%, 1%; gel 0.75%, 1%; lotion 0.75%; vaginal gel 0.75%
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Administer: Topical route • Topical skin products are not for intra- vaginal therapy and are for external use only; do not use skin products near the eyes, nose, or mouth • Wash hands before and after use; wash affected area and gently pat dry • Cream/gel/lotion: Apply a thin film to the cleansed affected area; massage gen- tly into affected areas Intravaginal route • Only use dosage formulations speci- fied for intravaginal use; intravaginal dosage forms are not for topical therapy; do not ingest • Avoid vaginal intercourse during treat- ment • Cream: Use applicator(s) supplied by the manufacturer
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Assess: • Allergic reaction: assess for hypersen- sitivity; product may need to be discon- tinued • Infection: assess for number of lesions and severity of acne rosacea, itching in vaginosis • Pregnancy/breastfeeding: not to be used in breastfeeding, systemic absorp- tion; use in pregnancy only if clearly needed, no adequate studies
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Evaluate: • Decreased severity of acne rosacea, infection in vaginosis
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CLINICAL CONSIDERATIONS
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Patient and caregiver information: • That topical skin products are not for intravaginal therapy and are for external use only; not to use skin products near the eyes, nose, or mouth • To wash hands before and after use; to wash affected area and gently pat dry • Cream/gel/lotion: to apply a thin film to the cleansed affected area and mas- sage gently into affected areas • Intravaginal route: to use only dosage formulations specified for intravaginal use; not to ingest intravaginal dosage forms because these are not for topical therapy; to avoid vaginal intercourse during treatment • Cream: to use applicator(s) supplied by the manufacturer
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• Adult: TOP apply to affected areas bid (0.75%) or daily (1%); adjust therapy based on response Bacterial vaginosis
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• Adult: VAG 1 applicatorful daily × 5 days
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