Drug reference

Micafungin

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 650, 651

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

Invasive candidiasis ▶BY INTRAVENOUS INFUSION ▶Adult (body-weight up to 40 kg): 2 mg/kg once daily for at least 14 days; increased if necessary to 4 mg/kg once daily, increase dose if response inadequate ▶Adult (body-weight 40 kg and above): 100 mg once daily for at least 14 days; increased if necessary to 200 mg once daily, increase dose if response inadequate Oesophageal candidiasis ▶BY INTRAVENOUS INFUSION ▶Adult (body-weight up to 40 kg): 3 mg/kg once daily ▶Adult (body-weight 40 kg and above): 150 mg once daily Prophylaxis of candidiasis in patients undergoing bone- marrow transplantation or who are expected to become neutropenic for over 10 days ▶BY INTRAVENOUS INFUSION ▶Adult (body-weight up to 40 kg): 1 mg/kg once daily continue for at least 7 days after neutrophil count is in desirable range ▶Adult (body-weight 40 kg and above): 50 mg once daily continue for at least 7 days after neutrophil count is in desirable range

PDF page 650

Safety

Interactions

→Appendix 1: micafungin

PDF page 650

Side Effects

Anaemia. anxiety. appetite decreased. arrhythmias. confusion. constipation. diarrhoea. disseminated intravascular coagulation. dizziness. drowsiness. dyspnoea. electrolyte imbalance. eosinophilia. ﬂushing. gastrointestinal discomfort. haemolysis. haemolytic anaemia. headache. hepatic disorders. hepatic failure (potentially life-threatening). hyperbilirubinaemia. hyperhidrosis. hypersensitivity. hypertension. hypoalbuminaemia. hypotension. insomnia. leucopenia. nausea. neutropenia. palpitations . pancytopenia. peripheral oedema. renal impairment. severe cutaneous adverse reactions (SCARs). shock. skin reactions. taste altered. thrombocytopenia. tremor. vomiting

PDF page 650

Pregnancy

Manufacturer advises avoid unless essential—toxicity in animal studies.

PDF page 650

Breast Feeding

Manufacturer advises use only if potential beneﬁt outweighs risk—present in milk in animal studies.

PDF page 650

Hepatic Impairment

Manufacturer advises caution in chronic impairment; avoid in severe impairment (limited information available).

PDF page 650

Renal Impairment

Use with caution; renal function may deteriorate.

PDF page 650

Monitoring Requirements

▶Monitor renal function. ▶Monitor liver function—discontinue if signiﬁcant and persistent abnormalities in liver function tests develop.

PDF page 650

Dose and formulations

Directions For Administration

For intravenous infusion (Mycamine ®), give intermittenly in Glucose 5% or Sodium chloride 0.9%. Reconstitute each vial with 5 mL infusion ﬂuid; gently rotate vial, without shaking, to dissolve; dilute requisite dose with infusion ﬂuid to 100 mL (ﬁnal concentration of 0.5–2 mg/mL); protect infusion from light; give over 60 minutes.

PDF page 650

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Powder for solution for infusion ▶Mycamine (Astellas Pharma Ltd) Micafungin (as Micafungin sodium) 50 mg Mycamine 50mg powder for solution for infusion vials | 1 vial P £196.08 Micafungin (as Micafungin sodium) 100 mg Mycamine 100mg powder for solution for infusion vials | 1 vial P £341.00 ANTIFUNGALS › POLYENE ANTIFUNGALS

PDF pages 650, 651

Dose text by age group

Adult (body-weight up to 40 kg)

2 mg/kg once daily for

First-line fragment. Read the complete Indications and Dose section above.

PDF page 650

Adult (body-weight 40 kg and above)

100 mg once daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 650

Adult (body-weight up to 40 kg)

3 mg/kg once daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 650

Adult (body-weight 40 kg and above)

150 mg once daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 650

Adult (body-weight up to 40 kg)

1 mg/kg once daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 650

Adult (body-weight 40 kg and above)

50 mg once daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 650

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

Micafungin

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 650, 651

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

PDF page 650

Safety

Interactions

→Appendix 1: micafungin

PDF page 650

Side Effects

PDF page 650

Pregnancy

Manufacturer advises avoid unless essential—toxicity in animal studies.

PDF page 650

Breast Feeding

Manufacturer advises use only if potential beneﬁt outweighs risk—present in milk in animal studies.

PDF page 650

Hepatic Impairment

Manufacturer advises caution in chronic impairment; avoid in severe impairment (limited information available).

PDF page 650

Renal Impairment

Use with caution; renal function may deteriorate.

PDF page 650

Monitoring Requirements

▶Monitor renal function. ▶Monitor liver function—discontinue if signiﬁcant and persistent abnormalities in liver function tests develop.

PDF page 650

Dose and formulations

Directions For Administration

PDF page 650

Medicinal Forms

PDF pages 650, 651

Dose text by age group

Adult (body-weight up to 40 kg)

2 mg/kg once daily for

First-line fragment. Read the complete Indications and Dose section above.

PDF page 650

Adult (body-weight 40 kg and above)

100 mg once daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 650

Adult (body-weight up to 40 kg)

3 mg/kg once daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 650

Adult (body-weight 40 kg and above)

150 mg once daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 650

Adult (body-weight up to 40 kg)

1 mg/kg once daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 650

Adult (body-weight 40 kg and above)

50 mg once daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 650

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.