Drug reference

Minocycline

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 621, 622

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

Susceptible infections (e.g. chlamydia, rickettsia and mycoplasma) ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Child 12–17 years: 100 mg twice daily Infection ▶Adult: 100 mg twice daily Acne ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Child 12–17 years: 100 mg once daily, alternatively 50 mg twice daily ▶Adult: 100 mg once daily, alternatively 50 mg twice daily ▶BY MOUTH USING MODIFIED-RELEASE MEDICINES ▶Child 12–17 years: 100 mg daily ▶Adult: 100 mg daily Prophylaxis of asymptomatic meningococcal carrier state (but no longer recommended) ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Adult: 100 mg twice daily for 5 days, minocycline treatment is usually followed by administration of rifampicin

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Cautions

Systemic lupus erythematosus

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Safety

Interactions

→Appendix 1: tetracyclines

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Side Effects

▶Rare or very rare Acute kidney injury. hearing impairment . respiratory disorders. tinnitus ▶Frequency not known Alopecia. antibiotic associated colitis. arthralgia. ataxia. breast secretion. conjunctival discolouration. drug reaction with eosinophilia and systemic symptoms (DRESS). dyspepsia. hyperbilirubinaemia. hyperhidrosis. polyarteritis nodosa. sensation abnormal. tear discolouration. tongue discolouration. vertigo

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Renal Impairment

Use with caution (avoid excessive doses).

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Monitoring Requirements

If treatment continued for longer than 6 months, monitor every 3 months for hepatotoxicity, pigmentation and for systemic lupus erythematosus—discontinue if these develop or if pre- existing systemic lupus erythematosus worsens.

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Dose and formulations

Directions For Administration

Tablets or capsules should be swallowed whole with plenty of ﬂuid while sitting or standing.

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Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: oral suspension, oral solution Tablet CAUTIONARY AND ADVISORY LABELS 6, 9 ▶Minocycline (Non-proprietary) Minocycline (as Minocycline hydrochloride) 50 mg Minocycline 50mg tablets | 28 tablet P £8.50 DT = £6.19 Minocycline (as Minocycline hydrochloride) 100 mg Minocycline 100mg tablets | 28 tablet P £14.50 DT = £14.18 Modified-release capsule CAUTIONARY AND ADVISORY LABELS 6, 25 ▶Acnamino MR (Dexcel-Pharma Ltd) Minocycline (as Minocycline hydrochloride) 100 mg Acnamino MR 100mg capsules | 56 capsule P £21.14 DT = £20.08 ▶Minocin MR (Mylan) Minocycline (as Minocycline hydrochloride) 100 mg Minocin MR 100mg capsules | 56 capsule P £20.08 DT = £20.08 Capsule CAUTIONARY AND ADVISORY LABELS 6, 9 ▶Aknemin (Almirall Ltd) Minocycline (as Minocycline hydrochloride) 100 mg Aknemin 100mg capsules | 28 capsule P £13.09 DT = £13.09 eiiii Infection F 597

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Clinical care

Patient And Carer Advice

Counselling on administration advised (posture). l LESS SUITABLE FOR PRESCRIBING Less suitable for prescribing (compared with other tetracyclines, minocycline is associated with a greater risk of lupus- erythematosus-like syndrome; it sometimes causes irreversible pigmentation).

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Dose text by age group

Child 12–17 years

100 mg twice daily

First-line fragment. Read the complete Indications and Dose section above.

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Adult

100 mg twice daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 621

Child 12–17 years

100 mg once daily, alternatively 50 mg

First-line fragment. Read the complete Indications and Dose section above.

PDF page 621

Adult

100 mg once daily, alternatively 50 mg twice

First-line fragment. Read the complete Indications and Dose section above.

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Child 12–17 years

100 mg daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 621

Adult

100 mg daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 621

Adult

100 mg twice daily for 5 days, minocycline

First-line fragment. Read the complete Indications and Dose section above.

PDF page 621

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

Minocycline

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 621, 622

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

PDF page 621

Cautions

Systemic lupus erythematosus

PDF page 621

Safety

Interactions

→Appendix 1: tetracyclines

PDF page 621

Side Effects

PDF page 621

Renal Impairment

Use with caution (avoid excessive doses).

PDF page 621

Monitoring Requirements

PDF page 621

Dose and formulations

Directions For Administration

Tablets or capsules should be swallowed whole with plenty of ﬂuid while sitting or standing.

PDF page 621

Medicinal Forms

PDF pages 621, 622

Clinical care

Patient And Carer Advice

PDF page 621

Dose text by age group

Child 12–17 years

100 mg twice daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 621

Adult

100 mg twice daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 621

Child 12–17 years

100 mg once daily, alternatively 50 mg

First-line fragment. Read the complete Indications and Dose section above.

PDF page 621

Adult

100 mg once daily, alternatively 50 mg twice

First-line fragment. Read the complete Indications and Dose section above.

PDF page 621

Child 12–17 years

100 mg daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 621

Adult

100 mg daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 621

Adult

100 mg twice daily for 5 days, minocycline

First-line fragment. Read the complete Indications and Dose section above.

PDF page 621

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.