Drug reference

Mivacurium

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 1430, 1431

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

Neuromuscular blockade (short duration) during surgery and intubation ▶INITIALLY BY INTRAVENOUS INJECTION ▶Adult: 70–250 micrograms/kg; (by intravenous injection) maintenance 100 micrograms/kg every 15 minutes, alternatively (by intravenous infusion) maintenance 8–10 micrograms/kg/minute, (by intravenous infusion) adjusted in steps of 1 microgram/kg/minute every 3 minutes if required; (by intravenous infusion) usual dose 6–7 micrograms/kg/minute DOSES AT EXTREMES OF BODY-WEIGHT ▶To avoid excessive dosage in obese patients, dose should be calculated on the basis of ideal body-weight.

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Cautions

Burns (low plasma cholinesterase activity; dose titration required). elderly

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Safety

Interactions

→Appendix 1: neuromuscular blocking drugs, non-depolarising

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Hepatic Impairment

Manufacturer advises caution in hepatic failure (increased duration of action). Dose adjustments Manufacturer advises dose reduction in hepatic failure.

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Renal Impairment

Dose adjustments Clinical effect prolonged in renal failure—reduce dose according to response.

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Dose and formulations

Directions For Administration

For intravenous infusion, give continuously in Glucose 5% or Sodium chloride 0.9%. Dilute to a concentration of 500 micrograms/mL; may also be given undiluted. Doses up to 150 micrograms/kg may be given over 5–15 seconds, higher doses should be given over 30 seconds. In asthma, cardiovascular disease or in those sensitive to reduced arterial blood pressure, give over 60 seconds.

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Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Solution for injection ▶Mivacron (Aspen Pharma Trading Ltd) Mivacurium (as Mivacurium chloride) 2 mg per 1 ml Mivacron 10mg/5ml solution for injection ampoules | 5 ampoule P £13.95 (Hospital only) Mivacron 20mg/10ml solution for injection ampoules | 5 ampoule P £22.57 (Hospital only) eiiii F 1407

PDF pages 1430, 1431

Dose text by age group

Adult

70–250 micrograms/kg; (by intravenous

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1430

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

Mivacurium

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 1430, 1431

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

PDF page 1430

Cautions

Burns (low plasma cholinesterase activity; dose titration required). elderly

PDF page 1430

Safety

Interactions

→Appendix 1: neuromuscular blocking drugs, non-depolarising

PDF page 1430

Hepatic Impairment

Manufacturer advises caution in hepatic failure (increased duration of action). Dose adjustments Manufacturer advises dose reduction in hepatic failure.

PDF page 1430

Renal Impairment

Dose adjustments Clinical effect prolonged in renal failure—reduce dose according to response.

PDF page 1430

Dose and formulations

Directions For Administration

PDF page 1430

Medicinal Forms

PDF pages 1430, 1431

Dose text by age group

Adult

70–250 micrograms/kg; (by intravenous

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1430

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.