Drug Action
Nateglinide stimulates insulin secretion.
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Drug reference
Nateglinide stimulates insulin secretion.
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Type 2 diabetes mellitus in combination with metformin when metformin alone inadequate ▶BY MOUTH ▶Adult: Initially 60 mg 3 times a day (max. per dose 180 mg), adjusted according to response, to be taken within 30 minutes before main meals
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Ketoacidosis
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Debilitated patients. elderly. malnourished patients CAUTIONS, FURTHER INFORMATION Manufacturer advises patients exposed to stress (including fever, trauma, infection or surgery) may require treatment interruption and temporary replacement with insulin to maintain glycaemic control.
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→Appendix 1: nateglinide
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▶Common or very common Diarrhoea. gastrointestinal discomfort. hypoglycaemia. nausea ▶Uncommon Vomiting ▶Rare or very rare Skin reactions ▶Frequency not known Appetite increased. dizziness. fatigue. muscle weakness. palpitations. sweating abnormal. tremor
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Avoid—toxicity in animal studies.
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Avoid—present in milk in animal studies.
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Manufacturer advises caution in moderate impairment; avoid in severe impairment (no information available).
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There can be variation in the licensing of different medicines containing the same drug. Tablet ▶Starlix (Novartis Pharmaceuticals UK Ltd) Nateglinide 60 mg Starlix 60mg tablets | 84 tablet P £26.12 DT = £26.12 Nateglinide 180 mg Starlix 180mg tablets | 84 tablet P £29.76 DT = £29.76
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Driving and skilled tasks Drivers need to be particularly careful to avoid hypoglycaemia and should be warned of the problems.
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Initially 60 mg 3 times a day (max. per dose
First-line fragment. Read the complete Indications and Dose section above.
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