Drug reference
Bowel sterilisation before surgery ▶BY MOUTH ▶Adult: 1 g every 1 hour for 4 hours, then 1 g every 4 hours for 2–3 days Hepatic coma Infection ▶BY MOUTH ▶Adult: Up to 4 g daily in divided doses usually for 5–7 days
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Intestinal obstruction. myasthenia gravis (aminoglycosides may impair neuromuscular transmission)
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Avoid prolonged use CAUTIONS, FURTHER INFORMATION Although neomycin is associated with the same cautions as other aminoglycosides it is generally considered too toxic for systemic use.
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→Appendix 1: neomycin
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Blood disorder. confusion. diarrhoea. drug cross-reactivity. electrolyte imbalance. gastrointestinal disorders. haemolytic anaemia. nausea. nephrotoxicity. nystagmus. oral disorders. ototoxicity. paraesthesia. superinfection. vomiting SIDE-EFFECTS, FURTHER INFORMATION Although neomycin is associated with the same side effects as other aminoglycosides, it is poorly absorbed after oral administration.
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There is a risk of auditory or vestibular nerve damage in the infant when aminoglycosides are used in the second and third trimesters of pregnancy.
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Manufacturer advises caution (increased risk of ototoxicity and nephrotoxicity).
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Avoid–risk of ototoxicity and nephrotoxicity.
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▶Renal function should be assessed before starting an aminoglycoside and during treatment. ▶Auditory and vestibular function should also be monitored during treatment.
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There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: oral solution Tablet ▶Neomycin sulfate (Non-proprietary) Neomycin sulfate 500 mg Neomycin 500mg tablets | 100 tablet P £34.69 DT = £34.69 eiiii F 543
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1 g every 1 hour for 4 hours, then 1 g every
First-line fragment. Read the complete Indications and Dose section above.
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Up to 4 g daily in divided doses usually for
First-line fragment. Read the complete Indications and Dose section above.
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