Drug reference
Insomnia (short-term use) ▶BY MOUTH ▶Adult: 5–10 mg daily, dose to be taken at bedtime, for Nervous system debilitated patients, use elderly dose ▶Elderly: 2.5–5 mg daily, dose to be taken at bedtime
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Chronic psychosis. respiratory depression
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Acute porphyrias p. 1120. hypoalbuminaemia. muscle weakness CAUTIONS, FURTHER INFORMATION ▶Paradoxical effects A paradoxical increase in hostility and aggression may be reported by patients taking benzodiazepines. The effects range from talkativeness and excitement to aggressive and antisocial acts. Adjustment of the dose (up or down) sometimes attenuates the impulses. Increased anxiety and perceptual disorders are other paradoxical effects.
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→Appendix 1: nitrazepam
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▶Common or very common Movement disorders ▶Uncommon Concentration impaired ▶Rare or very rare Abdominal distress. muscle cramps. psychiatric disorder. skin reactions. Stevens-Johnson syndrome ▶Frequency not known Drug abuse
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Benzodiazepines are present in milk, and should be avoided if possible during breast-feeding.
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Dose adjustments Start with small doses in severe impairment.
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There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: oral suspension Oral suspension CAUTIONARY AND ADVISORY LABELS 19 ▶Nitrazepam (Non-proprietary) Nitrazepam 500 microgram per 1 ml Nitrazepam 2.5mg/5ml oral suspension | 70 ml P £114.00 DT = £114.00 d Tablet CAUTIONARY AND ADVISORY LABELS 19 ▶Nitrazepam (Non-proprietary) Nitrazepam 5 mg Nitrazepam 5mg tablets | 28 tablet P £10.22 DT = £2.17 d ▶Mogadon (Mylan) Nitrazepam 5 mg Mogadon 5mg tablets | 30 tablet P £5.76 d eiiii F 359
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2.5–5 mg daily, dose to be taken at bedtime
First-line fragment. Read the complete Indications and Dose section above.
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