Names and pronunciation
(ni-za′ti-deen)
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Drug reference
(ni-za′ti-deen)
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Func. class.: H2-receptor antagonist
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Chem. class.: Substituted thiazole
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USES: Benign gastric and duodenal ulceration, prevention of duodenal ulcer recurrence, symptomatic relief of gastro- esophageal reflux, heartburn prevention
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CONTRAINDICATIONS: Hyper- sensitivity
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DOSAGE AND ROUTES Gastric and duodenal ulcer • Adult: PO 300 mg at night or 150 mg bid for 4-8 wk; maintenance 150 mg at night Prophylaxis of duodenal ulcer • Adult: PO 150 mg/day at bedtime Gastroesophageal reflux • Adult and child ≥12 yr: PO 150 mg bid × ≤12 wk, max 300 mg/day Heartburn prevention • Adult: PO 75 mg before eating bid Renal dose • Adult: PO CCr 20-50 mL/min, give 150 mg every other day; CCr <20 mL/min, give 150 mg q72hr HIGH ALERT
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• Adult and child ≥12 yr: PO 150 mg bid × ≤12 wk, max 300 mg/day Heartburn prevention
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