Names and pronunciation
(oh-bet-i-koe′lik as′id) Ocaliva
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Drug reference
(oh-bet-i-koe′lik as′id) Ocaliva
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Func. class.: Farnesoid X receptor agonist
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USES: Treatment of primary biliary cholangitis (PBC) in combination with ursodiol (ursodeoxycholic acid) with an inadequate response to ursodiol, or in those unable to tolerate ursodiol
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DOSAGE AND ROUTES Adult: PO Noncirrhotic or compen- sated Child-Pugh class A: Initial: 5 mg daily; if an adequate reduction in alkaline phosphatase and/or total bilirubin has not been achieved after 3 mo, increase to 10 mg daily, max 10 mg/day Hepatic dose • Adult: PO Child-Pugh B-C 5 mg weekly ×3 mo then increase as needed
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Available forms: Tabs 5, 10 mg HIGH ALERT
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• Adult: PO Child-Pugh B-C 5 mg weekly ×3 mo then increase as needed
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