Therapeutic Action
Antiulcer and gastric antisecretory agent (proton pump inhibitor)
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Drug reference
Antiulcer and gastric antisecretory agent (proton pump inhibitor)
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Gastro-oesophageal reflux Gastric and duodenal ulcers in adult
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Do not exceed 0.7 mg/kg daily (max. 20 mg daily) in patients with severe hepatic impairment. May cause: headache, diarrhoea, constipation, nausea, vomiting, abdominal pain, dizziness, skin rash, fatigue. Monitor combination with: atazanavir, itraconazole (decreased efficacy of these drugs); diazepam, phenytoin, digoxin, raltegravir (increased toxicity of these drugs). Pregnancy: no contra-indication Breast-feeding: no contra-indication
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10 mg dispersible gastro-resistant tablet 20 mg gastro-resistant capsule
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Gastro-oesophageal reflux Child under 5 kg: 0.7 to 1.4 mg/kg (max. 2.8 mg/kg daily) once daily in the morning Child 5 to 10 kg: 5 mg once daily in the morning Child 10 to 20 kg: 10 mg once daily in the morning Child over 20 kg and adult: 20 mg once daily in the morning 1 mg/ml sol. (a) 10 mg tablet (b) Age Weight 20 mg capsule < 2 months < 5 kg 3 ml – – 2 months to < 1 year 5 to < 10 kg 5 ml – – 1 to < 6 years 10 to < 20 kg – 1 tab – ≥ 6 years and adult ≥ 20 kg – – 1 cap a In a syringe, dissolve one 10 mg dispersible tablet in 10 ml of water to obtain a solution of 1 mg/ml. b Dissolve 1 dispersible tablet in half a glass of water. Gastric and duodenal ulcers Adult: 20 mg once daily in the morning In severe or recurrent cases, dose can be increased if necessary to 40 mg once daily.
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Gastro-oesophageal reflux: 3 days (short-term relief of symptoms) or 4 to 8 weeks (long-term treatment) Gastric and duodenal ulcers: 7 to 10 days or up to 8 weeks (severe or recurrent cases)
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Do not open capsules. Omeprazole is also used in combination with 2 antibacterial drugs for cure of Helicobacter pylori infection, at a dosage of 20 mg 2 times daily for 7 days.
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– Below 25 °C Once dissolved, dispersible tablets should be administered within 30 minutes.
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20 mg once daily in the morning
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20 mg once daily in the morning
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