Drug Action
Opicapone prevents the peripheral breakdown of levodopa, by inhibiting catechol- O- methyltransferase, allowing more levodopa to reach the brain.
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Drug reference
Opicapone prevents the peripheral breakdown of levodopa, by inhibiting catechol- O- methyltransferase, allowing more levodopa to reach the brain.
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Adjunct to co-beneldopa or co-careldopa in Parkinson’s disease with ‘end-of-dose’ motor fluctuations (under expert supervision) ▶BY MOUTH ▶Adult: 50 mg once daily, dose to be taken at bedtime, at least one hour before or after levodopa combinations
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Catecholamine-secreting neoplasms. history of neuroleptic malignant syndrome. history of non-traumatic rhabdomyolysis. paraganglioma. phaeochromocytoma
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Concurrent levodopa dose may need to be reduced. elderly over 85 years (limited information available)
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→Appendix 1: opicapone
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▶Common or very common Constipation. dizziness. drowsiness. dry mouth. hallucinations. headache. hypotension. movement disorders. muscle complaints. sleep disorders. vomiting ▶Uncommon Anxiety. appetite decreased. depression. dry eye. dyspnoea. ear congestion. gastrointestinal discomfort. hypertension. hypertriglyceridaemia. musculoskeletal stiffness. nocturia. pain in extremity. palpitations. syncope. taste altered. urine discolouration. weight decreased SIDE-EFFECTS, FURTHER INFORMATION Manufacturer advises consider liver function tests in patients who experience progressive anorexia, asthenia and weight decrease within a relatively short period of time.
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Manufacturer advises avoid—limited information available.
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Manufacturer advises avoid—no information available.
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Manufacturer advises caution in moderate impairment (risk of increased exposure); avoid in severe impairment (no information available). Dose adjustments Manufacturer advises consider dose reduction in moderate impairment.
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There can be variation in the licensing of different medicines containing the same drug. Capsule ▶Ongentys (BIAL Pharma UK Ltd) A Opicapone 50 mg Ongentys 50mg capsules | 30 capsule P £93.90 DT = £93.90
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50 mg once daily, dose to be taken at bedtime, at
First-line fragment. Read the complete Indications and Dose section above.
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