Indications
Prevention of poliomyelitis, in combination with the inactivated poliomyelitis vaccine (IPV)
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Drug reference
Prevention of poliomyelitis, in combination with the inactivated poliomyelitis vaccine (IPV)
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Do not administer in the event of severe immunodepression (risk of paralytic poliomyelitis): use the injectable vaccine IPV (asymptomatic HIV infection is not a contra-indication). Vaccination should be postponed in the event of severe acute febrile illness (minor infections are not contra-indications). May cause (exceptionally): paralytic poliomyelitis. In the event of vomiting or diarrhoea when the vaccine is administered, give the usual dose followed by an extra dose once gastrointestinal symptoms have improved. Respect an interval of at least 4 weeks between each dose. Pregnancy: no contra-indication Breast-feeding: no contra-indication
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Live-attenuated virus vaccine, bivalent (poliovirus types 1 and 3) Oral suspension in multidose vial, to be administered on the tongue, with dropper
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One dose = 2 drops (approximately 0.1 ml) In endemic areas or areas at risk of poliovirus importation, according to WHO recommendations Child: 4 doses approximately 4 weeks apart, at birth then at 6, 10 and 14 weeks of age th The 4 dose at 14 weeks is administered in combination with a dose of the inactivated poliomyelitis vaccine (IPV). Other areas Child: 3 doses approximately 4 weeks apart, at 6, 10 and 14 weeks of age rd The 3 dose at 14 weeks is administered in combination with a dose of the inactivated poliomyelitis vaccine (IPV).
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Protection against poliomyelitis lasts for life after 3 doses. In children who start routine vaccination late (after the age of 3 months), the dose of IPV is st administered together with the 1 dose of bOPV, followed by 2 doses of bOPV alone administered 4 weeks apart. For the vaccination schedule, follow national recommendations. Monovalent oral type 2 vaccines (mOPV and nOPV) are also available but are exclusively used for responding to epidemics.
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For prolonged storage: freeze (– 20 °C). After defrosting: between 2 °C and 8 °C for 6 months maximum.
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4 doses approximately 4 weeks apart, at birth then at 6, 10 and 14 weeks of age th
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3 doses approximately 4 weeks apart, at 6, 10 and 14 weeks of age rd
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