Drug Action
Orphenadrine exerts its antiparkinsonian action by reducing the effects of the relative central cholinergic excess that occurs as a result of dopamine deficiency.
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Drug reference
Orphenadrine exerts its antiparkinsonian action by reducing the effects of the relative central cholinergic excess that occurs as a result of dopamine deficiency.
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Parkinsonism | Drug-induced extrapyramidal symptoms (but not tardive dyskinesia) ▶BY MOUTH ▶Adult: Initially 150 mg daily in divided doses, then increased in steps of 50 mg every 2–3 days, adjusted according to response; usual dose 150–300 mg daily in divided doses; maximum 400 mg per day ▶Elderly: Preferably dose at lower end of range
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Acute porphyrias p. 1120. gastro- intestinal obstruction
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Cardiovascular disease. elderly. hypertension. in patients susceptible to angle-closure glaucoma. liable to abuse. prostatic hypertrophy. psychotic disorders. pyrexia
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→Appendix 1: orphenadrine
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▶Common or very common Accommodation disorder. anxiety. dizziness. dry mouth. gastrointestinal disorder. nausea ▶Uncommon Confusion. constipation. coordination abnormal. euphoric mood. hallucination. insomnia. sedation. seizure. tachycardia. urinary retention ▶Rare or very rare Memory loss
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Caution.
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Caution.
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Manufacturer advises caution.
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Use with caution.
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There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: oral solution Oral solution ▶Orphenadrine hydrochloride (Non-proprietary) Orphenadrine hydrochloride 10 mg per 1 ml Orphenadrine 50mg/5ml oral solution sugar-free | 150 ml P £45.30 DT = £42.76
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Avoid abrupt withdrawal in patients taking long-term treatment.
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Driving and skilled tasks May affect performance of skilled tasks (e.g. driving).
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Initially 150 mg daily in divided doses, then
First-line fragment. Read the complete Indications and Dose section above.
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Preferably dose at lower end of range
First-line fragment. Read the complete Indications and Dose section above.
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