Names and pronunciation
(o-tes-a-KAA-nuh-zowl) Vivjoa
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Drug reference
(o-tes-a-KAA-nuh-zowl) Vivjoa
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Func. class.: Antifungal, systemic
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Chem. class.: Azole ACTIONS: An azole inhibitor targeting the fungal sterol, which is required for fungal cell membrane formation and in- tegrity
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USES: Reduces the incidence of re- current vulvovaginal candidiasis (RVVC) in females with a history of RVVC who are NOT of reproductive potential
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CONTRAINDICATIONS: Pregnancy, breastfeeding, hypersensitivity Precautions: Renal/hepatic disease
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SIDE EFFECTS CNS: Headache GI: Nausea
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INTERACTIONS Increased: Breast cancer resistance pro- tein (BCRP) substrate effect, increases the risk of adverse reactions, a lower dose may be needed
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DOSAGE AND ROUTES Esophageal candidiasis • Adult: PO Oteseconazole-only dos- age regimen: On day 1: Give 600 mg (as a single dose). On day 2: Give 450 mg (as a single dose). Beginning on day 14: Give 150 mg once a week (q7days) × 11 wk (wk 2 through 12). Fluconazole/ oteseconazole dosage regimen: On day 1, day 4, day 7. Give fluconazole 150 mg PO; on days 14-20. Give oteseconazole 150 mg once daily × 7 days. Beginning on day 28: Give oteseconazole 150 mg once a week (every APPENDIX A 7 days) × 11 wk (wk 4-14)
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Available forms: Capsule 150 mg
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Administer: • Protect from light when removed from packaging, store at room temperature
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Assess: • Pregnancy/breastfeeding: do not use in pregnancy, may cause fetal harm; do not breastfeed
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Evaluate: • Therapeutic response: decreased can- didiasis
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CLINICAL CONSIDERATIONS
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Patient and caregiver information: • Women of childbearing age should use effective contraceptive
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PHARMACOKINETICS Peak 5-10 hr, half-life 139 days
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• Adult: PO Oteseconazole-only dos- age regimen: On day 1: Give 600 mg (as a single dose). On day 2: Give 450 mg (as a single dose). Beginning on day 14: Give 150 mg once a week (q7days) × 11 wk (wk 2 through 12). Fluconazole/ oteseconazole dosage regimen: On day 1, day 4, day 7. Give fluconazole 150 mg PO; on days 14-20. Give oteseconazole 150 mg once daily × 7 days. Beginning on day 28: Give oteseconazole 150 mg once a week (every APPENDIX A 7 days) × 11 wk (wk 4-14)
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