Indications And Dose
Severe pain requiring opioid analgesia in patients not currently treated with opioid analgesics ▶BY MOUTH ▶Adult: Initially 10/5 mg every 12 hours (max. per dose 40/20 mg every 12 hours), dose to be increased according to response; patients already receiving opioid analgesics can start with a higher dose Second-line treatment of symptomatic severe to very severe idiopathic restless legs syndrome after failure of dopaminergic therapy ▶BY MOUTH ▶Adult: Initially 5/2.5 mg every 12 hours, adjusted weekly according to response, usual dose 10/5 mg every 12 hours; maximum 60/30 mg per day continued → DOSE EQUIVALENCE AND CONVERSION ▶Dose quantities are expressed in the form x/y where x and y are the strengths in milligrams of oxycodone and naloxone respectively.
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