Drug Action
Palonosetron is a specific 5HT3-receptor antagonist which blocks 5HT3 receptors in the gastro- intestinal tract and in the CNS.
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Drug reference
Palonosetron is a specific 5HT3-receptor antagonist which blocks 5HT3 receptors in the gastro- intestinal tract and in the CNS.
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Moderately emetogenic chemotherapy ▶INITIALLY BY MOUTH ▶Adult: 500 micrograms, dose to be taken 1 hour before treatment, alternatively (by intravenous injection) 250 micrograms for 1 dose, dose to be administered over 30 seconds, 30 minutes before treatment Severely emetogenic chemotherapy ▶BY INTRAVENOUS INJECTION ▶Adult: 250 micrograms for 1 dose, dose to be administered over 30 seconds, 30 minutes before treatment
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History of constipation. intestinal obstruction. susceptibility to QT-interval prolongation (including electrolyte disturbances)
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→Appendix 1: palonosetron
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GENERAL SIDE-EFFECTS ▶Common or very common Constipation. headache SPECIFIC SIDE-EFFECTS ▶Common or very common ▶With intravenous use Diarrhoea. dizziness. electrolyte imbalance. metabolic disorder ▶Uncommon ▶With intravenous use Amblyopia. anxiety. appetite decreased. arrhythmias. arthralgia. asthenia. drowsiness. dry mouth. dyspepsia. euphoric mood. eye irritation. feeling hot. fever. flatulence. glycosuria. hiccups. hyperbilirubinaemia. hyperglycaemia. hypertension. hypotension. influenza like illness. motion sickness. myocardial ischaemia. paraesthesia. peripheral neuropathy. QT interval prolongation. skin reactions. sleep disorders. tinnitus. urinary retention. vasodilation. vein discolouration ▶With oral use Atrioventricular block. dyspnoea. eye swelling. insomnia. myalgia ▶Rare or very rare ▶With intravenous use Shock
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Avoid—no information available.
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Avoid—no information available.
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There can be variation in the licensing of different medicines containing the same drug. Solution for injection ▶Palonosetron (Non-proprietary) Palonosetron (as Palonosetron hydrochloride) 50 microgram per 1 ml Palonosetron 250micrograms/5ml solution for injection vials | 1 vial P £53.10 (Hospital only) | 10 vial P £646.90 ▶Aloxi (Chugai Pharma UK Ltd) Palonosetron (as Palonosetron hydrochloride) 50 microgram per 1 ml Aloxi 250micrograms/5ml solution for injection vials | 1 vial P £55.89 Capsule ▶Aloxi (Chugai Pharma UK Ltd) Palonosetron (as Palonosetron hydrochloride) 500 microgram Aloxi 500microgram capsules | 1 capsule P £55.89
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Driving and skilled tasks Dizziness or drowsiness may affect performance of skilled tasks (e.g. driving).
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500 micrograms, dose to be taken 1 hour before
First-line fragment. Read the complete Indications and Dose section above.
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250 micrograms for 1 dose, dose to be
First-line fragment. Read the complete Indications and Dose section above.
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