Indications And Dose
Moderately emetogenic chemotherapy | Highly emetogenic cisplatin-based chemotherapy ▶BY MOUTH ▶Adult: 1 capsule, to be taken approximately 1 hour before the start of each chemotherapy cycle
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Drug reference
Moderately emetogenic chemotherapy | Highly emetogenic cisplatin-based chemotherapy ▶BY MOUTH ▶Adult: 1 capsule, to be taken approximately 1 hour before the start of each chemotherapy cycle
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Patients over 75 years
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Scottish Medicines Consortium (SMC) decisions The Scottish Medicines Consortium (December 2015) has advised that palonosetron in combination with netupitant (Akynzeo ®) is accepted for restricted use within NHS Scotland for the prevention of acute and delayed nausea and vomiting associated with highly emetogenic cisplatin- based cancer chemotherapy.
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→Appendix 1: netupitant. palonosetron
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▶Common or very common Asthenia. constipation. headache ▶Uncommon Alopecia. cardiac conduction disorders. cardiomyopathy. diarrhoea. dizziness. flatulence. gastrointestinal discomfort. hiccups. hypertension. increased leucocytes. neutropenia. QT interval prolongation. sleep disorders. urticaria. vertigo ▶Rare or very rare Acute psychosis. arrhythmias. conjunctivitis. cystitis. dysphagia. feeling hot. hypokalaemia. hypotension. leucopenia. mitral valve incompetence. mood altered. myocardial ischaemia. numbness. pain. tongue coated. vision blurred
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Manufacturer recommends exclude pregnancy before treatment in females of childbearing age; ensure effective contraception during treatment and for one month after treatment.
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Manufacturer advises avoid—toxicity in animal studies.
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Manufacturer advises avoid during treatment and for 1 month after last dose—no information available.
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Manufacturer advises caution in severe impairment (risk of increased exposure, limited information available).
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There can be variation in the licensing of different medicines containing the same drug. Capsule Nervous system CAUTIONARY AND ADVISORY LABELS 25 ▶Akynzeo (Chugai Pharma UK Ltd) Palonosetron (as Palonosetron hydrochloride) 500 microgram, Netupitant 300 mg Akynzeo 300mg/0.5mg capsules | 1 capsule P £69.00 (Hospital only) ANTIHISTAMINES › SEDATING ANTIHISTAMINES
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1 capsule, to be taken approximately 1 hour
First-line fragment. Read the complete Indications and Dose section above.
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