Indications And Dose
Hypercalcaemia of malignancy ▶BY INTRAVENOUS INFUSION ▶Adult: 15–60 mg, to be given (via cannula in a relatively large vein) as a single infusion or in divided doses over 2–4 days, dose adjusted according to serum calcium concentration; maximum 90 mg per course Osteolytic lesions and bone pain in bone metastases associated with breast cancer or multiple myeloma ▶BY INTRAVENOUS INFUSION ▶Adult: 90 mg every 4 weeks, to be administered via cannula in a relatively large vein, dose may alternatively be administered every 3 weeks, to coincide with chemotherapy in breast cancer Paget’s disease of bone ▶BY INTRAVENOUS INFUSION ▶Adult: 30 mg every week for a 6 week course (total dose 180 mg), alternatively initially 30 mg once weekly for 1 week, then increased to 60 mg every 2 weeks (max. per dose 60 mg) for a 6 week course (total dose 210 mg), to be administered via cannula in a relatively large vein, course may be repeated every 6 months; maximum 360 mg per course
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