Drug reference

Pancuronium bromide

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 1431

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

Neuromuscular blockade (long duration) during surgery and intubation ▶BY INTRAVENOUS INJECTION ▶Adult: Initially 100 micrograms/kg, then 20 micrograms/kg as required Neuromuscular blockade (long duration) during intensive care ▶BY INTRAVENOUS INJECTION ▶Adult: Initially 100 micrograms/kg, initial dose is optional, then 60 micrograms/kg every 60–90 minutes DOSES AT EXTREMES OF BODY-WEIGHT ▶To avoid excessive dosage in obese patients, dose should be calculated on the basis of ideal body-weight.

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Safety

Interactions

→Appendix 1: neuromuscular blocking drugs, non-depolarising

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Side Effects

Apnoea. arrhythmia. hypersalivation. increased cardiac output. miosis SIDE-EFFECTS, FURTHER INFORMATION Pancuronium lacks histamine-releasing effect, but vagolytic and sympathomimetic effects can cause tachycardia.

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Hepatic Impairment

Manufacturer advises caution (possibly slower onset and higher dose requirements due to resistance to neuromuscular blocking action which may lead to a prolonged recovery time).

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Renal Impairment

Use with caution; prolonged duration of block.

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Dose and formulations

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Solution for injection ▶Pancuronium bromide (Non-proprietary) Pancuronium bromide 2 mg per 1 ml Pancuronium bromide 4mg/2ml solution for injection ampoules | 10 ampoule P £50.00 (Hospital only) eiiii F 1407

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Dose text by age group

Adult

Initially 100 micrograms/kg, then

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1431

Adult

Initially 100 micrograms/kg, initial dose is

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1431

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

Pancuronium bromide

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 1431

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

PDF page 1431

Safety

Interactions

→Appendix 1: neuromuscular blocking drugs, non-depolarising

PDF page 1431

Side Effects

PDF page 1431

Hepatic Impairment

Manufacturer advises caution (possibly slower onset and higher dose requirements due to resistance to neuromuscular blocking action which may lead to a prolonged recovery time).

PDF page 1431

Renal Impairment

Use with caution; prolonged duration of block.

PDF page 1431

Dose and formulations

Medicinal Forms

PDF page 1431

Dose text by age group

Adult

Initially 100 micrograms/kg, then

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1431

Adult

Initially 100 micrograms/kg, initial dose is

First-line fragment. Read the complete Indications and Dose section above.

PDF page 1431

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.