Names and pronunciation
(pah-ri-kal′si-tole) Zemplar
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Drug reference
(pah-ri-kal′si-tole) Zemplar
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Func. class.: Vitamin D analog
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USES: IV: Prevention/treatment of secondary hyperparathyroidism with chronic kidney disease on dialysis; PO: prevention/treatment with secondary hyperparathyroidism with stage 3/4 chronic kidney disease and stage 5 chronic kidney disease hemodialysis/peritoneal dialysis
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CONTRAINDICATIONS Hypersensitivity to paricalcitol or any com- ponent; vitamin D toxicity; hypercalcemia
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DOSAGE AND ROUTES Secondary hyperparathyroidism in chronic kidney disease on dialysis. • Adult: IV: Initial: 0.04-0.1 mcg/kg (2.8-7 mcg) given no more frequently than every other day at any time during dialysis; adjust dose based on serum in- tact PTH (iPTH), as follows: iPTH above target and increased: Increase by 2-4 mcg every 2-4 wk; maximum dose: 0.24 mcg/kg/day; iPTH above target and de- creased by <30%: Increase by 2-4 mcg every 2-4 weeks; maximum dose: 0.24 mcg/kg/day; iPTH above target and de- creased by 30-60%: Maintain paricalcitol dose; iPTH above target, decreased dose
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Available forms: Capsule 1, 2, 4 mcg; injection 2, 5 mcg/mL
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• Adult: IV: Initial: 0.04-0.1 mcg/kg (2.8-7 mcg) given no more frequently than every other day at any time during dialysis; adjust dose based on serum in- tact PTH (iPTH), as follows: iPTH above target and increased: Increase by 2-4 mcg every 2-4 wk; maximum dose: 0.24 mcg/kg/day; iPTH above target and de- creased by <30%: Increase by 2-4 mcg every 2-4 weeks; maximum dose: 0.24 mcg/kg/day; iPTH above target and de- creased by 30-60%: Maintain paricalcitol dose; iPTH above target, decreased dose
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